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Tizanidine was the 89th most commonly prescribed drug in the United States in 2017. In that year alone, there were over nine million prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long tizanidine stays in your system.

Experts state the following information regarding tizanidine half-life:

Mean effective half-life: Two hours

Time to steady-state: four days

Mean accumulation ratio: N/A

Terminal phase half-life: Two hours

Tizanidine has an oral bioavailability of 40 percent. While this drug does absorb, it may take up to three doses for it to reach a steady-state. 


What is the half-life of tizanidine?

Two hours.

How long does tizanidine stay in your system?

Tizanidine is detectable in your system for the following time frames:

  • Your blood for 10 days
  • Your saliva for 24 to 48 hours
  • Your urine for five to 13 days
  • Your hair for two or three days

Tizanidine is not a controlled substance that would show up in standard 12-panel drug tests but it is detectable in blood, saliva, urine, and hair. 

Can I take two tizanidine 4 mg at once?

Always follow the recommended dose for medication. For most, that includes an initial dose of 4mg. The patient adds another 4 mg tablet after about a week. Doses are three times a day, so that would be a total of 24 mg daily. One should not advance to three 4 mg tablets per dose without consulting their physician, though. 

If after a week of taking one 4 mg tablet per dose, if it is necessary to take another, for most that would be okay unless the medical provider advises against it.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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