OverviewDosageSide EffectsInteractionsHalf-Life

How Much Tylenol Can I Take with Tramadol?

Ultracet is the common brand name for Tylenol (acetaminophen) and tramadol in one tablet. It is a prescription drug used to relieve pain. The safest dosage will differ from person to person. Your doctor will be able to provide the best dosage for Tylenol and/or tramadol based on your medical history, any other medication(s) you take and your current health needs.

Does Tylenol Enhance Tramadol?

According to Mayo Clinic, using Tylenol(acetaminophen) with tramadol (Ultracet) increases pain relief. People use the two medicines together in the form of Ultracet under a doctor’s guidance when one or the other does not provide enough pain relief.

Acetaminophen, apart from tramadol, is an over-the-counter medicine people use to reduce fever or pain, while tramadol is a prescription drug often prescribed for extreme pain. Acetaminophen comes in much smaller doses and strength, and it is much less addictive which is why it is available over the counter. It is important to understand that taking the two together is not advisable unless under a doctor’s supervision and advice. Tylenol(acetaminophen) is a commonly overdosed medication in the United States and so should be taken with caution. To learn more about the dosages of tramadol, visit our dosage page.

What Medications Should Not Be Taken with Tylenol and Tramadol (Ultracet)?

Just like with any other medication, you should check with your doctor about possible drug interactions before taking Ultracet. Common drug interactions with Ultracet, according to Mayo Clinic, include:

  • Antihistamines
  • Certain cold medicines
  • Certain medications used for anxiety or depression
  • Prescription pain medicine or narcotics
  • ADHD and ADD medications
  • Seizure medications
  • Muscle relaxants
  • Sleep medicines, including sleep apnea medications
  • Alcohol
  • Any other drug combinations with acetaminophen in them

Note that this list is not complete, and other drug interactions with Ultracet may occur than what is listed here.

What medications should not be taken with Tramadol?

The FDA has listed many interactions for tramadol. You can read our page on tramadol interactions to learn more.

What pain relief can be taken with Tramadol?

Before taking any pain reliever with tramadol, ask your doctor about any possible interactions. Remember, tramadol and Tylenol together is known as Ultracet and is prescribed for acute pain that is too severe to be treated with over-the-counter pain relievers alone. Your doctor might prescribe Ultracet for advanced pain relief if they believe your symptoms are not resolving with just tramadol.

Your doctor may also add other alternative medications if the pain relief is not sufficient with tramadol. Always follow exactly what your physician prescribes especially with pain medication.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


More about Tramadol

Written by

Medically reviewed by