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According to the FDA, the following serious adverse reactions of hydroxyzine are discussed in greater detail in other sections:

  • Dry mouth
  • Drowsiness
  • Involuntary motor activity

Adverse Reactions

Side effects reported with the administration of hydroxyzine are usually mild and transitory in nature. Many of the below reactions are rare.

Skin and Appendages: Oral hydroxyzine hydrochloride is associated with fixed drug eruptions (Or an allergic reaction (Ex. lesion) that appears in the same places when taking medication) in post-marketing reports.

Anticholinergic: Dry mouth.

Central Nervous System: Drowsiness is usually transitory and may disappear in a few days of continued therapy or upon reduction of the dose. Involuntary motor activity, including rare instances of tremor and convulsions, has been reported, usually with doses considerably higher than those recommended. Clinically significant respiratory depression has not been reported at recommended doses.

In post-marketing experience, the following additional undesirable effects have been reported:

Body as a Whole: allergic reaction

Nervous System: headache

Psychiatric: hallucination

Skin and Appendages: pruritus, rash, urticaria.

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