OverviewDosageSide EffectsInteractionsHalf-Life

The following information comes from DailyMed, an FDA label information provider.

Adverse Reactions

Common side effects of taking Citalopram include but are not limited to:

  • Nausea and/or vomiting
  • Dry mouth
  • Insomnia
  • Tremors
  • Diarrhea
  • Abdominal pain
  • Fatigue
  • Fever
  • Anxiety
  • Vertigo
  • Headaches and/or migraines
  • Muscle spasms/contractions
  • Teeth grinding
  • Hiccups
  • Alcohol intolerance
  • Hay fever

Please note this list may not be complete. If you experience serious side effects during your treatment with Citalopram, call your doctor immediately,

Dose Dependency of Adverse Events

The potential relationship between the dose of Celexa administered and the incidence of adverse events was examined in a fixed-dose study in depressed patients receiving placebo or Celexa 10, 20, 40, and 60 mg. Jonckheere’s trend test revealed a positive dose response (p<0.05) for the following adverse events: fatigue, impotence, insomnia, sweating increased, somnolence, and yawning.

Male and Female Sexual Dysfunction with SSRIs

Although changes in sexual desire, sexual performance, and sexual satisfaction often occur as manifestations of a psychiatric disorder, they may also be a consequence of pharmacologic treatment. In particular, some evidence suggests that SSRIs can cause such untoward sexual experiences.

Reliable estimates of the incidence and severity of untoward experiences involving sexual desire, performance, and satisfaction are difficult to obtain, however, in part because patients and physicians may be reluctant to discuss them. Accordingly, estimates of the incidence of untoward sexual experience and performance cited in product labeling, are likely to underestimate their actual incidence.

The table below displays the incidence of sexual side effects reported by at least 2% of patients taking Celexa in a pool of placebo-controlled clinical trials in patients with depression.

TreatmentCelexa (425 males)Placebo (194 males)
Abnormal Ejaculation (mostly ejaculatory delay)6.1% (males only)1%
(males only)
Libido Decreased3.8% (males only)<1%
(males only)
Impotence2.8% (males only)<1%
(males only)

In female depressed patients receiving Celexa, the reported incidence of decreased libido and anorgasmia was 1.3% (n=638 females) and 1.1% (n=252 females), respectively.

There are no adequately designed studies examining sexual dysfunction with citalopram treatment.

Priapism has been reported with all SSRIs.

While it is difficult to know the precise risk of sexual dysfunction associated with the use of SSRIs, physicians should routinely inquire about such possible side effects.

Vital Sign Changes

Celexa and placebo groups were compared with respect to (1) mean change from baseline in vital signs (pulse, systolic blood pressure, and diastolic blood pressure) and (2) the incidence of patients meeting criteria for potentially clinically significant changes from baseline in these variables. These analyses did not reveal any clinically important changes in vital signs associated with Celexa treatment. In addition, a comparison of supine and standing vital sign measures for Celexa and placebo treatments indicated that Celexa treatment is not associated with orthostatic changes.

Weight Changes

Patients treated with Celexa in controlled trials experienced a weight loss of about 0.5 kg compared to no change for placebo patients.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.



OVERVIEW
DOSAGESIDE EFFECTSINTERACTIONSHALF-LIFE

Generic Name: Citalopram HBr

Brands: Celexa

Class: Antidepressant [Selective Serotonin Reuptake Inhibitor (SSRI)]

Availability: Prescription only

Molecular Formula: C20H22BrFN2O

Substance UNII: I1E9D14F36

What is Citalopram?

Citalopram is a selective serotonin reuptake inhibitor (SSRI) given as a prescription. It is the generic name of the trade name Celexa.

What is Citalopram Used For?

Citalopram is an antidepressant that is used to treat depression. When used as an antidepressant, it is designed to bring about better mental balance by improving a person’s mood by increasing the serotonin levels present in the brain.

During certain occasions, medical professionals may also prescribe this drug to treat other conditions such as alcoholism, eating disorders, social phobia (excessive interaction anxiety), panic disorders, and premenstrual dysphoric disorder, according to MedlinePlus. This list of conditions that citalopram is prescribed for is not complete, as you should speak with a medical professional regarding additional uses. Since citalopram can be prescribed for conditions other than what it was originally approved for by the FDA, it is considered an off-label drug and has off-label uses.

How Does Citalopram Work?

Citalopram is a selective serotonin reuptake inhibitor (SSRI) used to increase the serotonin levels in the brain. Serotonin is a chemical created naturally by the body that helps with certain bodily functions, such as digestion and bowel movements. It is also believed that serotonin helps to regulate a person’s mood.

When serotonin levels are low, a person may experience a low mood and symptoms of depression. Citalopram prevents the nerve cells from reabsorbing the serotonin. By blocking this reabsorption, it helps to increase the levels of serotonin that are present for the brain. The higher serotonin levels available for the brain helps to improve the person’s mood.

How Long Does It Take for Citalopram to Work?

Citalopram can take anywhere from 1 to 4 weeks before a person starts to see noticeable results. It can be prescribed as a tablet or as a solution. It may be taken with or without food.

Do Not Use Citalopram If:

There are several situations where taking this medication may not be the right choice for a person.  According to the FDA, you should not use citalopram if having these conditions or experiencing these situations:

  • Taking MAOIs
  • After stopping treatment of MAOIs for 14 days
  • Concomitant use of pimozide
  • Having a hypersensitivity to citalopram or its inactive ingredients

Please understand that this list of contradictions may not be complete. There may possibly be other situations where starting the use of this drug is not advisable.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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