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Below are the general guidelines for doing Pantoprazole. Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking Pantoprazole.

The following information comes from DailyMed, an FDA label information provider.

What if I miss a dose of Pantoprazole?

According to Mayo Clinic, if you miss a dose of Pantoprazole, take it immediately unless you are closer to the time of your next dose. Never double doses.

What if I overdose on Pantoprazole?

Experience in patients taking very high doses of pantoprazole (greater than 240 mg) is limited.  Spontaneous post-marketing reports of overdose are generally within the known safety profile of pantoprazole.

Pantoprazole is not removed by hemodialysis. In case of overdosage, treatment should be symptomatic and supportive. 

Single oral doses of pantoprazole at 709 mg/kg, 798 mg/kg, and 887 mg/kg were lethal to mice, rats, and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. 

If overexposure to Pantoprazole occurs, call your Poison Control Center at 1-800-222-1222 for current information on the management of poisoning or overdosage.

Dosage and Administration

Pantoprazole sodium is supplied as delayed-release tablets. The recommended dosages are outlined in Table 1.   

IndicationDoseFrequency
Short-Term Treatment of Erosive Esophagitis Associated With GERD
 Adults           40 mgOnce daily for up to 8 weeks*
Children (5 years and older)
≥ 15 kg to < 40 kg
≥ 40 kg
20 mg
40 mg
Once daily for up to 8 weeks
Maintenance of Healing of Erosive Esophagitis
Adults40 mgOnce daily***
Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome
Adults40 to 80 mgTwice daily**
* For adult patients who have not healed after 8 weeks of treatment, an additional 8-week course of pantoprazole sodium delayed-release tablets may be considered.
** Dosage regimens should be adjusted to individual patient needs and should continue for as long as clinically indicated. Doses up to 240 mg daily have been administered.
*** Controlled studies did not extend beyond 12 months  

Administration Instructions

Directions for method of administration are presented in Table 2.

Formulation Route Instructions*
Delayed-Release Tablets Oral Swallowed whole, with or without food 
*Do not split, chew, or crush Pantoprazole sodium delayed-release tablets.

Take a missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular scheduled time. Do not take 2 doses at the same time.

Swallow Pantoprazole sodium delayed-release tablets whole, with or without food in the stomach. For patients unable to swallow a 40 mg tablet, two 20 mg tablets may be taken. Concomitant administration of antacids does not affect the absorption of Pantoprazole sodium delayed-release tablets.

How is Pantoprazole supplied?

Pantoprazole sodium delayed-release tablets, USP are supplied as 40 mg white to pale yellow colored, oval shape, biconvex, enteric-coated tablets, plain on one side and “97” printed with brown ink on the other side.

They are available as follows:

Overbagged with 10 tablets per bag, NDC 55154-7634-0

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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