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Just like with any other medication, there will be some instances in which Otezla (apremilast) may interact with other medications, foods, or medical conditions. It is important to discuss with your prescribing physician about possible interactions before you begin treatment with Otezla.

Please note that the following list of interactions may not be complete. Your physician will monitor the risks and side effects of varying drug interactions, based on your individual health profile.

The following information comes from the FDA label.

Drug Interactions

According to the FDA, drugs that may interact with Otezla include:

  • Strong cytochrome P450 inducers, including rifampin, phenobarbital, carbamazepine, and phenytoin – These inducers may reduce the efficacy of Otezla.
  • There may be other interactions not listed

Food Interactions


For more information on the interaction between Otezla and alcohol, please visit our alcohol interactions page.

Condition & Disease Interactions


The FDA states the importance of disclosing to your prescribing physician if you have a history of depression or suicidal thoughts or behaviors, as Otezla has the potential to increase those symptoms.

Otezla and Pregnancy

For more information, please visit our page on Otezla and pregnancy.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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