OverviewDosageSide EffectsInteractionsHalf-Life

Generic Name: apremilast

Brands: Otezla

Class: immunosuppressant, phosphodiesterase 4 (PDE4) inhibitor

Availability: Prescription needed

Molecular Formula: C22H24N2O7S

Substance UNII: 2R4D1XUZ78

What is Otezla?

Otezla is a prescription medication used to treat various types of arthritis or psoriasis.

What is Otezla used for?

Otezla can treat psoriatic arthritis in adults and plaque psoriasis.

How does Otezla work?

Otezla is a small-molecule inhibitor of phosphodiesterase 4 (PDE4). When PDE4 is inhibited, intracellular cAMP (cyclic adenosine monophosphate) levels increase, and an anti-inflammatory result is produced. cAMP is responsible for various biological tasks and responses. 

How long does it take Otezla to work?

The amount of time it takes for Otezla to have effects may differ from one person to another. It may take up to 16 weeks of treatment for this medication to work, as noted by the FDA.

Do not use Otezla if:

There are some cases in which a person should not use Otezla, including but not limited to:

  • If you have a history of depression and/or suicidal thoughts or behavior
  • Hypersensitivity to apremilast (Otezla)

Please note this list is not complete, and therefore, it is critical that you speak with your doctor about the potential risks of taking Otezla, based on your individual health profile.

For more information regarding interactions with Otezla, please visit our interactions page.

For more information regarding side effects with Otezla, please visit our side effects page.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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