Study Overview
Details
NCTId: NCT02002559
Status: Completed
Condition: Superficial Esophageal Neoplasia
Study Type: Observational
Sponsor: Chinese University of Hong Kong
Study Description
Brief
This study aimed to compare Narrow Band Imaging (NBI) against Lugol chromoendoscopy for diagnosis of early esophageal cancers among high risk patients.
Detailed
The investigators recruited consecutive patients with head and neck cancers, history of squamous esophageal cancers treated by chemoradiotherapy or endoscopic resection. Endoscopic surveillance first started with NBI for detection and characterization of early esophageal cancers through observation of abnormal intrapapillary capillary loops (IPCL). Superficial esophageal neoplasia were diagnosed by IPCL Type IV, V1,V2 and Vn. Lugol chromoendoscopy would be performed subsequently and suspicious neoplasia were classified as understain or unstain lesions. The diagnostic accuracy, sensitivity and specificity of NBI were compared to Lugol chromoendoscopy with histology serving as a gold standard.
Eligibility
Criteria:
Inclusion Criteria:
Patients with Head and Neck Cancer
Patients with esophageal cancer treated by chemoradiotherapy and in remission for 2 years
Patients with esophageal cancer treated by endoscopic resection
Age 18 to 80
Exclusion Criteria:
Allergy to Lugol iodine
Pregnancy
Previous esophagectomy
Healthy Volunteers: No
Gender: All
Min Age: 18 Years
Max Age: 80 Years
