when is the best time to take glucosamine chondroitin msm

Glucosamine, chondroitin, and methylsulfonylmethane (MSM) are the best-known supplements prescribed to ease the symptoms of arthritis and other joint-related conditions. But like in all things, timing is everything, and it may (or may not) increase a (group of) supplement’s efficacy.

So what’s the best time to take glucosamine chondroitin msm? This article will discuss the truths you need to know…  

The Optimal Time To Take Glucosamine Chondroitin & MSM

The time of day you take a glucosamine, chondroitin, and MSM supplement does not notably influence its therapeutic impact on joint health and alleviation of discomfort.

However, we have found, that the best time to take it is typically in the morning with a meal to enhance absorption, create a repeatable habit, and minimize potential gastrointestinal discomfort.

However, always consult with a healthcare professional before starting any new supplement regimen.

Understanding Glucosamine, Chondroitin, and MSM

What Are They, And How Do They Benefit Joint Health?


A naturally occurring amino acid found in the cartilage with anti-inflammatory effects, relieving mild to moderate osteoarthritis. One study found glucosamine effective in relieving pain caused by osteoarthritis in the knee, endorsing it as an ideal supplement to treat patients with such conditions.

In supplement form, glucosamine is harvested from shellfish shells and manufactured in pharmaceutical laboratories. Several forms of glucosamine include glucosamine sulfate, hydrochloride, and N-acetyl glucosamine. 


A natural compound found in connective tissue, chondroitin is made of amino acids and glucosamine sulfate. Being a major component of cartilage, It supposedly helps protect the cartilage in joints, prevents it from further damage, and provides pain relief.

While experts are mixed regarding its efficacy, some studies back up its analgesic properties and claim that it has significant clinical benefits, like preventing cartilage degradation and stimulating its repair mechanisms.

Supplemental chondroitin comes from animal sources like sharks, pigs, and cows and can be produced synthetically.  It’s usually sold in combination with glucosamine sulfate.


Methylsulfonylmethane (MSM) is a sulfur-containing compound in plants, animals, and humans. It’s widely used in alternative medicine to relieve joint pain, reduce inflammation, and boost immunity.

Studies show that it can help reduce joint pain and swelling and improve function in people with osteoarthritis. Others claim it also benefits aging skin, hay fever, and many other conditions, but more scientific studies and trials have yet to be done to establish these claims.

Evolution of Glucosamine, Chondroitin, and MSM Usage

The use of glucosamine, chondroitin, and MSM for arthritis relief is fairly recent, with the National Institutes of Health estimating that 6.5 million adults in the United States have used one or both of these products. It’s also a common osteoarthritis treatment in Europe. 

Maryland-based epidemiologist Dr. Chris D’Adamo attests to the potential of these medications when used together. A 2016 trial of this trio found them effective at relieving knee osteoarthritis pain and swelling without any side effects, while another trial found the combination helped prevent cartilage degeneration. 

However, reviews of studies have yielded mixed results about these supplements. Some found the supplements offered pain relief and function compared to placebo, while others didn’t. The outcome difference may be due to the various supplement types and doses researchers used. 

Optimal Timing for Consumption

There is no ideal time to take glucosamine and chondroitin with MSM supplements. Studies show that the time of day doesn’t alter their efficacy and that what matters is that they are taken around meal times at any time of the day (as one prefers) to increase their absorption and efficacy in the body. 

While others prefer taking supplements on an empty stomach, some people have reported experiencing indigestion, bloating, nausea, or heartburn. Taking them before or after a meal can mitigate these side effects. 

Dosage Recommendations

A typical dose or recommended daily amount (RDA) of glucosamine chondroitin with MSM can go from 500 mg to 1200 mg, depending on the severity of the arthritis symptoms. 

If the dosage is too minimal or strong, you can consult your doctor to adjust it to avoid side effects and increase efficiency. 

FAQ Section

Does the time of day I take glucosamine chondroitin MSM affect its efficacy?

Experts say that the time of day doesn’t significantly increase or decrease their efficacy but stress the importance of consuming them before or after a meal.  

Can I take glucosamine chondroitin MSM on an empty stomach?

Taking it on an empty stomach is not restricted per se, but it may cause some side effects in some people. Taking it with food is generally recommended to enhance absorption and efficacy.

How long does it take to see results from taking glucosamine chondroitin MSM?

Results can vary depending on the person’s dosage and response to the supplements, but others report recovery after 1 to 2 months of consistent supplementation.

Are there any side effects associated with glucosamine chondroitin MSM?

Some individuals may experience stomach problems after taking them, especially without meals. 

Can I take glucosamine chondroitin MSM with other medications?

Individually, the compounds may interact with other medications you may already be taking, so it’s essential to consult with a healthcare professional to avoid possible interactions.


  • Glucosamine, chondroitin, and methylsulfonylmethane (MSM) are supplements that combat symptoms of arthritis and other joint-related conditions, especially when taken together.
  • Experts say that the time of day doesn’t significantly increase or decrease their efficacy but stress the importance of consuming them before or after a meal.  


Taking glucosamine and chondroitin with MSM is a promising and effective way to manage (osteo)arthritis symptoms, and when paired with a healthy diet and lifestyle, it can yield faster recovery. 

If you’re considering taking these supplements together, consult your healthcare provider to help you determine the proper dose for your pain levels and help work you through the best options to relieve arthritis symptoms.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

Written by