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Research shows that people who use Zoloft (sertraline) tend to experience a mild yet noticeable weight gain over the long term. So, just what should patients know about Zoloft and weight gain?


Why does Zoloft make you gain weight?

Like other selective serotonin reuptake inhibitors (SSRIs), sertraline can cause weight gain, although researchers are still working to figure out why. Weight gain may be the result of the effects SSRIs (like Zoloft) has on serotonin levels in the brain. While serotonin is mainly responsible for improved mood, it can also affect the appetite, causing the consumer to feel hungrier or less hungry. The use of Zoloft may also cause people to feel less satisfied after a meal, which can cause them to eat larger portions or consume foods that are higher in calories.

How can I avoid gaining weight on Zoloft?

The best ways to avoid gaining weight on Zoloft is to make minor dietary changes that include lower-calorie food choices. Adding physical activity will help burn off excess calories, and can even reduce symptoms of depression. Switching to another SSRI may help the consumer avoid weight gain. For instance, switching to a non-SSRI, such as Wellbutrin (bupropion), may also help.

Does Zoloft slow down your metabolism?

There is not much evidence that Zoloft slows down metabolism. In fact, research shows that Zoloft does not affect the function of the thyroid, which is the gland that controls metabolism.

Does everyone gain weight on Zoloft?

Not everyone will gain weight on Zoloft. In fact, some might even lose weight. Although, research shows that many people who use Zoloft experience a mild, but noticeable weight gain.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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