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Sertraline (Zoloft) is just one antidepressant treatment – other types of drug treatments and therapies may be suitable Zoloft alternatives.

Zoloft Alternatives

What are the options when it comes to alternatives for Zoloft?

Talk Therapies

Some patients respond to “talking therapies,” such as cognitive behavioral therapy, intrapersonal therapy, counseling, and self-help groups.

Other Antidepressants

Others find benefit in exercise. Many people with depression, anxiety, and other mental health issues may use alternative selective serotonin reuptake inhibitors (SSRIs), such as:

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac, Prozac Weekly, Sarafem)
  • Fluvoxamine (Luvox, Luvox CR)
  • Paroxetine (Paxil, Paxil CR, Pexeva)

For Anxiety

Like sertraline, Escitalopram (Lexapro) is a selective serotonin reuptake inhibitor (SSRI). This fact means it works by increasing the brain’s levels of serotonin. Which one is more effective depends largely on the individual, as research has come to mixed conclusions about their comparable efficacy. Some research, for example, suggests Lexapro is more effective. Other studies, though, show that Zoloft is as good as or even better than Lexapro.

Without Weight Gain

Many antidepressants are associated with weight gain; Zoloft is no exception. For those looking to avoid weight gain, bupropion (Wellbutrin) may be the solution. It is the only antidepressant that research suggests leads to long-term weight loss.


What is the best natural antidepressant?

Research suggests St. John’s wort reduces symptoms of mild to moderate depression more than a placebo, and provides results similar to prescription antidepressants. Another study found St. John’s wort provides benefits similar to prescription antidepressants on mild to moderate depression, and that fewer people stopped taking St. John’s wort compared to prescription antidepressants.

It’s important to note that St. John’s wort has many food and drug interactions. Patients must always consult with their medical providers before using St. John’s wort or any other over-the-counter supplement.

What other drug is similar to Zoloft?

Prozac and Zoloft are similar, in that they are both brand-name prescription medications used to treat depression and other mental health issues. Both Prozac and Zoloft are selective serotonin reuptake inhibitors (SSRIs), so they work in similar ways.

Which antidepressant has the least side effects?

A side-by-side comparison of the most commonly prescribed antidepressants and their side effects shows that Prozac and Zoloft can cause adverse effects, such as dry mouth, blurred vision, dizziness, drowsiness, jitteriness, sleep problems, digestive issues, weight gain and sexual problems. However, Prozac presented a very low risk of digestive issues, whereas Zoloft presented a low risk of digestive side effects.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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