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Sertraline (Zoloft) is not recommended for everyone, and prescribers may have to adjust dosages in some cases to prevent or reduce the risk of unwanted Zoloft interactions with other drugs, medical conditions, or even food and beverages.

Drug Interactions

According to the FDA, drugs that may interact with Zoloft include the following:

  • Monoamine oxidase inhibitors (MAOIs), commonly used to treat depression and Parkinson’s disease
  • Pimozide (Orap), commonly used to reduce uncontrollable body movements and vocal tics
  • Other drugs that affect serotonin, such as other serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac)
  • Anticoagulants (blood thinners), such as warfarin (Jantoven)
  • Drugs that bind to proteins in the blood, such as warfarin (Jantoven)
  • Drugs metabolized by the enzyme CYP2D6, such as propafenone (Rythmol SR), used to treat or prevent heart rhythm problems
  • Phenytoin (Phenytek), used to prevent and treat epileptic seizures

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Zoloft and Melatonin

There are no known interactions between Zoloft and melatonin. However, it is still a good idea to consult your medical provider before taking the two together.

Zoloft and Ibuprofen

Using Zoloft and ibuprofen (Advil) together may increase the risk of bleeding, particularly in consumers who are elderly or who have liver or kidney disease.

Food Interactions

Food and beverages can sometimes interact with medications to cause unwanted side effects or to alter the effects of the medications.

Food and drink that may interact with Zoloft include:

  • Alcohol

Please note that this list may not be complete, and other foods and beverages may interact with this drug.

Zoloft and Alcohol

For more information, please visit our page on sertraline and alcohol interactions.

Disease & Conditions Interactions

Medications can sometimes cause negative side effects in patients with certain medical conditions. According to the FDA, diseases and medical conditions known to interact negatively with Zoloft include:

  • Liver disease

Please note that this list may not be complete, and there may be diseases and medical conditions that interact with this medication.

Zoloft and Pregnancy

For more information, please visit our page on Zoloft and pregnancy risks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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