Sertraline (Zoloft) is not recommended for everyone, and prescribers may have to adjust dosages in some cases to prevent or reduce the risk of unwanted Zoloft interactions with other drugs, medical conditions, or even food and beverages.
According to the FDA, drugs that may interact with Zoloft include the following:
- Monoamine oxidase inhibitors (MAOIs), commonly used to treat depression and Parkinson’s disease
- Pimozide (Orap), commonly used to reduce uncontrollable body movements and vocal tics
- Other drugs that affect serotonin, such as other serotonin reuptake inhibitors (SSRIs) like fluoxetine (Prozac)
- Anticoagulants (blood thinners), such as warfarin (Jantoven)
- Drugs that bind to proteins in the blood, such as warfarin (Jantoven)
- Drugs metabolized by the enzyme CYP2D6, such as propafenone (Rythmol SR), used to treat or prevent heart rhythm problems
- Phenytoin (Phenytek), used to prevent and treat epileptic seizures
Please note that this list may not be complete, and other interactions with drugs not listed here may occur.
Zoloft and Melatonin
There are no known interactions between Zoloft and melatonin. However, it is still a good idea to consult your medical provider before taking the two together.
Zoloft and Ibuprofen
Using Zoloft and ibuprofen (Advil) together may increase the risk of bleeding, particularly in consumers who are elderly or who have liver or kidney disease.
Food and beverages can sometimes interact with medications to cause unwanted side effects or to alter the effects of the medications.
Food and drink that may interact with Zoloft include:
Please note that this list may not be complete, and other foods and beverages may interact with this drug.
Zoloft and Alcohol
For more information, please visit our page on sertraline and alcohol interactions.
Disease & Conditions Interactions
Medications can sometimes cause negative side effects in patients with certain medical conditions. According to the FDA, diseases and medical conditions known to interact negatively with Zoloft include:
- Liver disease
Please note that this list may not be complete, and there may be diseases and medical conditions that interact with this medication.
Zoloft and Pregnancy
For more information, please visit our page on Zoloft and pregnancy risks.