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Sertraline (Zoloft) was the 14th most commonly prescribed drug in the United States in 2017. In that year alone, there were 38,296,630 prescriptions for the drug. Considering this popularity, it pays to know a little bit more about this medication, including how long Zoloft stays in your system.

DrugBank states the following information regarding Zoloft half-life:

Mean effective half-life: approximately 26 hours

Time to steady-state: 1 week following once-daily administration

Zoloft has an oral bioavailability of greater than 44 percent. The body readily metabolizes and breaks down sertraline, the active ingredient in Zoloft. After metabolizing this drug, the body excretes the metabolites in urine and feces.

FAQ

What is the half-life of Zoloft?

Zoloft has a half-life of approximately 26 hours.

How long does Zoloft stay in your system?

The active ingredient in Zoloft, sertraline, takes about six days to clear from the body. However, the body breaks down sertraline into metabolites, which can take up to two weeks to clear the body.

How long does it take for Zoloft to wear off?

The active ingredient in Zoloft, sertraline, takes about six days to clear from the body. However, the body breaks down sertraline into metabolites, which can take up to two weeks to clear the body.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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