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Propranolol was the 51st most commonly prescribed drug in the United States in 2018. In that year alone, there were over 14.5 million prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long propranolol stays in your system.

Basic Information

Mean effective half-life: 3 to 6 hours

Time to steady-state: N/A

Mean accumulation ratio: 1.49

Terminal phase half-life: 3 to 6 hours

Propranolol has an oral bioavailability of 25%. Although propranolol is readily absorbed, it has a high first-pass metabolism rate in the liver, which means only about 25 percent of it reaches the circulation. The peak plasma concentrations occur between one and four hours after the oral dose. 


What is the half-life of propranolol?

The half-life of propranolol is from three to six hours. 

How long does propranolol stay in your system?

It is not clear if propranolol shows up in standard drug tests and is not routinely part of such tests. The drug tends to be completely out of the system in just one to two days, though. 

What is the half-life of propranolol 10 mg?

The half-life for the propranolol 10 mg film-coated tablets is two to six hours.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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