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Best NMN Supplement – NMN capsules are exciting scientists with their cell repair powers – encouraging the repair of cell damage, increased energy and endurance, anti-aging benefits, and fighting cardiovascular diseases. Consumers can harness these superpowers by using the best NMN supplement.

In this article, we give you a deeper understanding of what NMN supplements are and the many benefits NMN supplements provide. We also share some of the side effects are of NMN capsules and our reviews of the top five NMN supplements around. 

With this guide, you can make an informed decision when selecting your NMN supplement to give you optimum benefits.

What Is NMN?

Nicotinamide Mononucleotide (NMN) molecule is a naturally-forming molecule found in our bodies. Along with nicotinamide riboside (NR or Niagen), it builds a critical energy-generating molecule called nicotinamide adenine dinucleotide (NAD+). Together, they are responsible for vital functions in our bodies.

It also regulates and monitors the creation of hormones in our endocrine system. Hormonal balance is key for building muscle, immune function, digestion, and even keeping happy. 

This synergy of these heroic molecules helps with anti-aging and fighting age-related illnesses. These include cardiovascular diseases, diabetes, and neurodegeneration. They also support the immune system and are important for mitochondria – our cells’ powerhouses that generate energy. 

There are many proponents of using the highest quality NMN supplements, The professor of genetics and Harvard Medical School, David Sinclair uses NMN as part of his daily routine.

NMN Vs. NR

Nicotinamide Mononucleotide (NMN) and nicotinamide riboside (NR or Niagen) both essentially perform the same function – the building of NAD+. However, in the body’s process of converting these compounds to NAD+, nicotinamide riboside naturally transforms into NMN, and together they use Nuclear Magnetic Resonance (NMR) to help build up NAD+.

The difference between the two comes down to size. Nicotinamide Mononucleotide (NMN) is the larger molecule of the two and needs to be broken down to fit into a cell. 

This is where cellular transporters come in. These are basically “doorways” into cells, allowing molecules to enter without the need to chemically transform.

There are currently no studies that prove one to be better than the other. However, some experts argue that Nicotinamide Mononucleotide (NMN) is one step ahead of nicotinamide riboside. Essentially, it’s one step further down the pathway to form NAD+. 

NR has to be phosphorylated (the chemical addition of a phosphoryl group to an organic molecule) to create NMN. Only then will your body begin to synthesize NAD+.

NMN Has More Effects

Because Nicotinamide Mononucleotide (NMN) is essentially more processed than NR, it’s shown to improve various aging symptoms which NR has not. 

It’s also possibly effective in the treatment of Alzheimer’s. NMN repairs cellular damage in the brain. Supporting studies, however, are only in the early stages, so there’s no definitive proof one way or the other.

NR is unstable in the bloodstream and is quickly degraded into vitamin B3. This means that large quantities of NR are broken down before they can be absorbed to where they’re needed.

A comprehensive look at related studies leans slightly towards stronger and more diverse effects from NMN than NR. These include improved insulin sensitivity, better bone density, better mitochondrial functioning, and a stronger immune system.

Improvements in aging and a reduction of symptoms from age-related diseases have been seen more typically with NMN than NR.

Potential Natural Compound Against Insulin Resistance

Studies have shown that Nicotinamide Mononucleotide (NMN) can have positive effects on insulin sensitivity and signaling. Resistance to insulin increases with age and with age-related diseases – the more resistant our tissues are to insulin, the faster they age.

Insulin resistance is also associated with type-2 diabetes, making NMN particularly attractive to diabetics and prediabetics.

How NMN Works

As we grow older, environmental factors such as pollution, radiation, and imprecise DNA replication due to aging cause DNA damage. Almost all cells contain molecular engines to repair this damage, and they use NAD+ and energy metabolism to do so. Emerging research and clinical trials find that Nicotinamide Mononucleotide (NMN) optimizes NAD and helps restore organ systems to a healthy state.

Reduced levels of Nicotinamide Mononucleotide, NAD+, and sirtuins disturb the process of regenerating cells, resulting in rapid aging. The best NMN supplements can be taken to support an increase in this regeneration power. So if you have low NAD levels it could be beneficial to begin taking nicotinamide mononucleotide in supplement form.

There are various categories of the best NMN supplements available on the market, each with different benefits and delivery methods.

NMN Powder

This is the cheapest form of NMN supplement. It’s also, unfortunately, the most difficult for the body to absorb. 

When powdered liposomal NMN (lipo NMN) and NR enter the stomach and digestive system unprotected (by a capsule, for example), stomach acid breaks it down into NAM (nicotinamide) before it’s able to reach the tissues and cells that need support. 

Increasing your dosage of NMN powder won’t work to circumnavigate this, as this leads to excessive NAM which has health consequences. 

Sublingual NMN

Sublingual NMN is a Nicotinamide Mononucleotidesupplement that is dissolved under the tongue, which means it bypasses the liver and therefore more of it makes it into the bloodstream. Sublingual NMN is a more expensive form of NMN, but this is because sublingual delivers NMN and faster ingestion giving you a quick boost of energy. We recommend bulk sublingual NMN powder and pharmaceutical-grade NMN supplements for maximum benefits.

Intranasal NMN

Intranasal NMN is one of the best options for getting NMN to the brain, being able to bypass the blood-brain barrier. It requires lower doses, has fewer side effects, and has seen excellent increases of NMN in the brain. 

Intranasal NMN is most common in the form of nasal spray bottles.

Liposomal NMN

Liposomes are small fatty shells that encase the Nicotinamide Mononucleotide (NMN). Liposomal NMN supplements are ingested orally as capsules, and the presence of the liposomes prevents degradation of the NMN in the stomach, so more of it can be absorbed by the body.

Liposomes also help with sustained release of the NMN, which results in a consistent increase of NAD+ over 24 hours.

Health Benefits of NMN

The true power of NMN capsules lies in what it promotes inside the cells – the integrity of our DNA. And healthy DNA improves health and wellness in every part of our bodies. Let’s take a look at all of the potential benefits of these anti-aging supplements.

Improved Heart Function

Your heart is constantly at work, whether you’re running a marathon or fast asleep, so it requires a constant supply of energy. NAD boosters give the heart this energy. 

DNA Repair and Maintenance

DNA damage is something we all experience during our lives. Age and environmental effects can all lead to damage to our DNA. The older you are, the more these errors in our DNA compound and amino acids, and is a direct precursor to illness and disease.

DNA damage can result in auto-immune dysfunctionality, which lowers the body’s defense against diseases like cancer. 

Sirtuins, which are activated by Nicotinamide Mononucleotide, stabilize and repair these chromosome ends – meaning they fix the damage – and the body’s resistance to disease increases.

Enhances Mitochondrial Function

Mitochondria are the powerhouses of our cells, converting molecules from the food we eat into energy. NAD+ is at the center of this process. 

NMN keeps mitochondria fueled, and when there’s not enough NMN, we lose NAD+. When we lose NAD+, mitochondrial function decreases, which means our bodies can’t convert food into fuel. 

This can lead to conditions such as neurological disorders such as Alzheimer’s disease as vital biological functions lack the nutrients and energy they need.

Muscle Health and Blood Circulation

Healthy muscles are vital for quality of life in our old age. NMN supplementation helps our muscles to improve energy metabolism.

Skeletal muscle mass keep us active and moving in our daily lives. To do this, they need energy from molecules like glucose and fatty acids, which come from NAD+. 

NAD+ metabolizes these molecules, delivering energy to our muscle mass, which require a steady supply of their building blocks, NMN. By increasing the availability of NMN, your muscular system can more easily bring in the resources it needs to maintain itself.

Risks Associated With NMN

The primary risk of the best NMN supplements is what they’re combined with. Third-party reports have revealed that some products include heavy metals, impurities, and other banned substances. 

There are also cases where products don’t even contain NMN, and what is labeled as an NMN supplement is really a powder or capsule filled with something else. 

You need to be mindful of which supplement you choose. Arm yourself with information before you make your purchase, and always read the label carefully. You can also chat with your pharmacist to give you some guidance and advice.

5 Best NMN Booster Supplements (Our Review) 

We investigated and reviewed many, many NMN capsules products: chatting to experts and reading up on the most recent studies. 

Here are our top five, which have all been put through third-party testing.

Sublingual NMN

This form of NMN supplement is dissolved under the tongue, which means it bypasses the liver and therefore more of it makes it into the bloodstream. It’s a more expensive form of NMN, but this is because of its faster ingestion giving you a quick boost of energy.

Intranasal NMN

Intranasal NMN is one of the best options for getting NMN to the brain, being able to bypass the blood-brain barrier. It requires lower doses, has fewer side effects, and has seen excellent increases of NMN in the brain. 

Intranasal NMN is most common in the form of nasal spray bottles.

Liposomal NMN

Liposomes are small fatty shells that encase the NMN. Liposomal NMN supplements are ingested orally as capsules, and the presence of the liposomes prevents degradation of the NMN in the stomach, so more of it can be absorbed by the body.

Liposomes also help with sustained release of the NMN, which results in a consistent increase of NAD+ over 24 hours.

Health Benefits of NMN

NMN’s true superpower lies in what it promotes inside the cells – the integrity of our DNA. And healthy DNA improves health and wellness in every part of our bodies. Let’s take a look at all of the potential benefits of these anti aging supplements.

Improved Heart Function

Your heart is constantly at work, whether you’re running a marathon or fast asleep, so it requires a constant supply of energy. NAD+ gives the heart this energy. 

DNA Repair and Maintenance

DNA damage is something we all experience during our lives. Age and environmental effects can all lead to damage to our DNA. The older you are, the more these errors in our DNA compound, leading to illness and disease.

DNA damage can result in auto-immune dysfunctionality, which lowers the body’s defense against diseases like cancer. 

Sirtuins, which are activated by NMN, stabilize and repair these chromosome ends – meaning they fix the damage – and the body’s resistance to disease increases.

Enhances Mitochondrial Function

Mitochondria are the powerhouses of our cells, converting molecules from the food we eat into energy. NAD+ is at the center of this process. 

NMN keeps mitochondria fueled, and when there’s not enough NMN, we lose NAD+. When we lose NAD+, mitochondrial function decreases, which means our bodies can’t convert food into fuel. 

This can lead to conditions such as neurological disorders such as Alzheimer’s disease as vital biological functions lack the nutrients and energy they need.

Muscle Health and Blood Circulation

Healthy muscles are vital for quality of life in our old age. NMN supplementation helps our muscles to improve energy metabolism.

Skeletal muscles keep us active and moving in our daily lives. To do this, they need energy from molecules like glucose and fatty acids, which come from NAD+. 

NAD+ metabolizes these molecules, delivering energy to our muscles, which require a steady supply of their building blocks, NMN. By increasing the availability of NMN, your muscular system can more easily bring in the resources it needs to maintain itself.

Risks Associated With NMN

The primary risk of NMN supplements is what they’re combined with. Third-party reports have revealed that some products include heavy metals, impurities, and other banned substances. 

There are also cases where products don’t even contain NMN, and what is labeled as an NMN supplement is really a powder or capsule filled with something else. 

You need to be mindful of which supplement you choose. Arm yourself with information before you make your purchase, and always read the label carefully. You can also chat with your pharmacist to give you some guidance and advice.

5 Best NMN Booster Supplements (Our Review) 

We investigated and reviewed many, many NMN products: chatting to experts and reading up on the most recent studies. 

Here are our top five, which have all been put through third-party testing.

1. Ultra Health – Pharmaceutical Grade NMN

This product is 100% the strongest NMN supplementation with no preservatives or excipients. The manufacturer created a proprietary synthesis method to take the NMN through three crystallization processes. This ensures maximum bioavailability, allowing your body to absorb as much of it as possible.

The crystallization process also enhances chemical purity and improves reaction yield. Because this product is pharmaceutical grade, it carries a higher price tag. But at 250mg of an NMN dose per capsule, it gives one of the highest doses of active ingredients per capsule.

Ultra Health NMN supplements are good for people who are interested in an anti-aging supplement, appearance, and who live an active lifestyle. 

Pros

• Restores neurovascular coupling
• Improves insulin activity and production
• Alleviates metabolic conditions 
• 60 capsules
• 250g NMN supplementation per capsule

2. Alive by Science – Liposomal NAD+ & NMN

This product from Alive By Science NMN utilizes only liposomal NAD booster and NMN in powdered liposomal supplement form to protect and combine NMN and NAD+ from breaking down in digestive enzymes in your stomach. In Alive By Science, the liposomes increase bioavailability in the body, making more liposomal NMN products and NAD+ available for absorption.

The combination in these nutriop NMN supplements by Alive By Science features liposomal NMN capsules that allow for NAD+ to cross the blood-brain barrier for delivery to cells in the brain as a nootropics depot NMN dose, while also effectively reaching other necessary parts of the body.

Alive By Science and liposomal technology has undergone extensive testing, being triple-lab tested, and is free from impurities.

While the Alive By Science supplement itself has been thoroughly vetted for quality, there seem to be some issues in the packaging plant. Some users have reported getting their supplements with broken or damaged capsules, making them unsafe to consume.

Pros

• Greater bioavailability
• Cost-saving
• Enhanced delivery of NMN
• Non-toxic and biologically biodegradable

Cons

• Capsule leakage

3. California Gold Nutrition NMN Supplement

This product has the added benefit of containing Lavitol – a bioflavonoid extract of dihydroquercetin which is a powerful antioxidant. This extract forms part of the flavonoid complex of an NMN dose, Lavitol, and Apigenin – an active ingredient in chamomile tea that has traditionally been used to help with anxiety and stress reduction. 

Current research, clinical trials, and human trials, however, is finding that Apigenin aids in anti-aging, working alongside the NMN dose to increase sirtuins and NAD+.

Pros

• Gluten-free
• No soy
• No GMOs

Cons

• High doses could lead to liver complications

4. Doublewood Nicotinamide Mononucleotide

The double wood stabilized NMN booster supplement contains 250mg per serving (2 capsules). This is a solid option at an affordable price point.

If you buy Double wood NMN, you’d notice that it has been third-party tested for the quality and accuracy of its chemical compound claims. You can see those test results here. This is an important factor to consider when trying to find the best nmn supplement in a fairly new market.

Pros

• 250mg NMN per serving
• Gluten-free
• Soy-free
• Made in the USA
• Made without solvents
• Third party tested

Cons

• Can lead to stomach discomfort 
• Capsule made from bovine gelatin so not suitable for vegans

5. Peak Performance NMN + Resveratrol

*Discontinued

We love this product because it combines an NMN dose with Resveratrol. Resveratrol is a polyphenol compound found in certain plants. It’s believed to act as an antioxidant, protecting the body against damage from free radicals. 

Resveratrol works hand in hand with NMN supplementation as an accelerator to enhance DNA repair. 

Quality, Potency, and Purity

The quality, potency, and purity of this NMN dose is another reason it ranks highly with our team. All ingredients are sourced from clean, safe environments, which the manufacturers further enhance with strict quality control procedures. 

Every batch is tested, and artificial processing is avoided to ensure the preservation of the maximum mineral nutrients.

Anti-aging

Peak Performance NMN supplementation supports NAD+ to produce more energy and proteins to repair damaged cells to slow the aging process. Combined with Resveratrol, the efficacy of this supplement is amplified as well as vascular health and blood flow.

This aids in repairing the cells and DNA, which supports muscular health and strength, improves vascular health and blood flow, and slows the anti-aging process. The two active ingredients in this supplement are the two most frequently used in the life extension community.

Vegan and Allergy-free

This product is suitable for anyone who struggles with allergies and for vegans. The NMN capsules contain no gluten or preservatives and is free of wheat, peanuts, shellfish, eggs, corn, and soy. 

Peak Performance NMN supplements are manufactured under the highest quality USA standards and GMP regulations as determined by the FDA. 

Be mindful that extended use and overdosing of a low NMN dose can lead to nausea, vomiting, diarrhea, or liver toxicity dysfunction.

Pros

• Antioxidant 
• Lowers risk of cancer
• Improves cardiovascular health
• Works to protect NMN and neuro-protection, including Alzheimer′s, Huntington′s, and Parkinson′s
• Anti-inflammatory

Cons

• Extended use can have side effects

Nicotinamide Mononucleotide Supplement FAQs

NMN Content Comparison Chart by Brand

The chart below shows the NMN content in mg of each of the 5 brands we have featured in this article.

Why we ranked each NMN brand

As you can see, most of the brands contain 250mg of Nicotinamide Mononucleotide. We found Ultra Health to be the best of the there brands that contained this mg of NMN.

We ranked Peak Performance’s NMN highly despite the lower mg levels of NMN because it combines this with resveratrol, allowing you to condense two supplements into one.

David Sinclair Discussing NMN Supplementation

Conclusion

Our exploration of NMN supplements and their benefits leads us to conclude that these supplements should become a part of our lifestyles.

Using the right supplement and in the correct dosages is the key to obtaining maximum benefit from NMN and increase NAD levels that will in turn help with the aging process. Have this conversation with your physician if you are considering including this supplement in your diet.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.