Best Berberine Supplement

Finding the best berberine supplement could be the key to improving your overall mental and physical health. Berberine has been used to treat obesity, diabetes, and metabolic diseases. Plants containing berberine have long been used in traditional medicines and treatments across the world.

It’s used to treat inflammatory disorders, wounds, skin diseases, to reduce fevers, eye health, tumors, and digestive and respiratory diseases. Some of the key nutritional benefits include maintaining healthy cholesterol and blood sugar levels, promoting GI microbial balance, and supporting a healthy metabolism.

Berberine activates the AMP-activated protein called a kinase. Kinase assists in the regulation of blood sugar levels. By activating this enzyme berberine helps to treat diabetes and other health-related issues you might be dealing with, such as high cholesterol and obesity.

Berberine is also used to fight against a variety of chronic diseases, such as Inflammatory Bowel Disease, Alzheimer’s disease, rheumatoid arthritis, and cardiovascular diseases, this is due to its multiple-target effect. Adding a berberine supplement to your diet is essential in maintaining a healthy and energized body.

Let’s have a look at which berberine supplement works best for you.

Best Berberine Supplements (Our Review)

1. Nuzena – Berberine Pure +

This is one of the top-rated berberine supplements on the market today.

It’s also one of the most powerful options. It has 1200 mg of berberine extract per two-capsule serving.

Nuzena’s Berberine Pure + supplement is an excellent value-for-money supplement. It’s affordable and proven to be a quality product. 

For around $40, you’ll receive a 60-day supply of the supplement delivered straight to your door.

It has the highest amount of pure berberine in each capsule of any other berberine supplement on our list.

Taking two capsules daily will contribute to a healthy and more active metabolism.

If you’re looking for a berberine supplement with no added filler ingredients, then Nuzena Berberine Pure + is the best option for you. 

There are no unnecessary ingredients in this formula. It’s designed to lower your cholesterol, increase metabolism, and maintain blood sugar levels, among a list of other health benefits.

You will benefit the most from this product if you suffer from type two diabetes that leads to metabolic syndrome. Research has shown that Berberine lowers glucose levels in diabetics, which helps to regulate blood sugar.

Berberine also helps to activate the Kinase enzyme. This enzyme is sometimes referred to as the “metabolic master switch.” It’s found in the cells of a variety of organs, including the brain, kidney, muscles, liver, and heart. Kinases play a huge role in regulating your metabolism.

By regulating your metabolic activity, kinases aid in the increase of energy production. This leads to better function of your organs and digesting foods. Cells repair easier which makes it particularly useful for athletes recovering from sports injuries.

A boost in metabolism also means you burn more calories, resulting in weight loss and a slimmer waist.


  • Pure berberine, with no added ingredients.
  • Great for overall health
  • Value for money
  • 600mg of pure and concentrated berberine per capsule
  • Gluten-free and vegan-friendly


  • If you have any underlying conditions, consult your doctor before taking this product


  • Berberine

2. Peak Performance – GlucoVantage Super Berberine 

Compared to other berberine supplements, Super Berberine is highly absorbable and 5X more bioavailable. It is the first commercial brand that is an active metabolite of berberine.

In comparison to other berberine supplements, it is 2X longer-lasting.

It’s linked to lower GI stress compared to regular berberine. It has been shown to lower sugar and glucose levels and insulin sensitivity.

It’s vegan and allergy-free. There’s no soy, milk, corn, shellfish, peanuts, or wheat. It contains no gluten or preservatives. It’s also Keto-friendly and plant-based. Whatever diet you’re on, or whatever foods you’re restricted from eating, odds are that GlucoVantage will be safe for you.

It contains DHB (Dihydroberberine) which is a metabolite of berberine. This ensures that the supplement absorbs faster and more potently.

DHB has significantly greater functional benefits. It inhibits fat cell growth and insulin sensitivity. This helps your body respond to carbs and insulin better.

The DHB forces the carbs you eat to be stored in your muscles as glycogen. This in turn is used by your body as energy, instead of storing it away as fat.

Regardless of your gender, if you’re seeking to lose weight and improve your insulin sensitivity, then this product is for you. It has been proven to be an effective weight loss supplement.

Berberine has been shown to aid in the reduction of the appetite-stimulating hormone leptin. This means you’ll be getting hungry less often and, in return, eating less.

Taking a berberine supplement over three months has shown significant weight loss.

The bottle contains 30 capsules. You can take one or two servings a day before a meal. Each capsule is 100 mg.


  • Linked to lower GI stress
  • Vegan friendly. Allergy-free. No preservatives
  • Highly absorbable
  • Bioavailable
  • 2x Longer lasting than regular berberine


  • Might clash with certain medications. Check with your medical practitioner before taking this supplement


  • Berberine
  • Vegetable cellulose: Great source of fiber, this has no known side effects. It has a gel-like consistency and is all-natural. It’s used to make the capsule and is easily digestible
  • Cellulose capsule: this is an anti-caking substance that helps the berberine powder flow in the capsule

3. Alive By Science – LIPO Berberine

This brand of highly concentrated liposomal berberine comes in 150 mg capsules.

There are 90 capsules per bottle, providing a three-month supply for just under $50. These easy-to-swallow capsules boast superior absorption before reaching your stomach.

An enteric coating protects the ingredients from breaking down in the stomach and intestines so the berberine is delivered where it’s needed most.

It also increases blood circulation, which ensures a continuous flow throughout your body, allowing every organ to function properly and any wounds to heal faster.

They can be taken with or without food, once a day.

It aids in weight loss and regulates blood sugar and insulin metabolism.

One of the main functions of the supplement activates an enzyme called AMPK, which regulates your metabolism.

It also slows down the accumulation of depleted cells by inducing autophagy. Autophagy is your body’s way of cleaning out damaged, dysfunctional, and toxic cells and proteins.

It is an evolutionary self-preservation mechanism that we developed to combat the effects of these toxic cells and proteins, which lead to chronic diseases and other age-related illnesses.

Berberine is also responsible for increasing your metabolism by increasing and regulating the molecules that maintain the epigenome. These are chemical compounds and proteins that attach to your DNA. This is beneficial for your overall health and well-being.


  • Affordable
  • Reduces liver toxicity
  • Improves maximum nutrient absorption
  • Supports weight loss
  • Targeted and Advanced absorption


  • Not be suitable for people with a sensitive stomach. May cause gastric upset.


  • Berberine
  • Rice Flour: used as an anti-caking substance in a capsule.
  • Vegetable Cellulose (capsule): an essential dietary nutrient and used as an alternative to animal-sourced gluten. It is easily absorbable and has no side effects.
  • Microcrystalline Cellulose: refined wood pulp, that is used in vitamin supplements and tablets as a bulking agent or anti-caking agent.

4. Healthy Directions Clinical Grade Berberine 1500mg

Berberine Healthy Directions

This clinically graded berberine supplement is highly recommended by the world-renowned Dr. Whitaker, founder of the Whitaker Wellness Clinic. 

The berberine is contained in capsules of 500 mg, which are to be taken three times a day to reach the recommended dose of 1500 mg per day. For the best results, take these capsules with a meal to get the maximum results.

The containers come with 90 capsules for a 30-day supply of berberine.

A full dosage (1500 mg a day) has been shown to support a healthy glucose response. Taken daily the berberine ensures your blood glucose levels remain in the normal range.

Patients with elevated cholesterol and triglyceride levels who take at least 1000 mg of berberine a day were shown to be healthier overall, with their triglycerides and cholesterol levels greatly improved.

For those suffering from type two diabetes, the berberine supplement is safe and well-tolerated by most people.

Its powerful properties help to manage blood sugar levels, which can fluctuate throughout the day. If not treated properly, this could lead to serious organ damage and other health issues.

The ingredients of your medication can clash with berberine. Consult your healthcare provider before starting this supplement.

Research has shown that berberine can be as effective at stabilizing your blood sugar levels as some conventional diabetic medication, which is great, especially if you aren’t able to take diabetes medication due to serious health conditions, such as heart, liver, or kidney disease.


  • Contains 1500 mg of Berberine daily for advanced maintenance and health benefits
  • Formulated by an expert in the field of integrative and preventive medicine.
  • Clinically validated ingredients


  • Cannot be used if you have a serious medical condition and use any of the medications. 


  • Berberine HCl

5. Thorne Berbercap Berberine

Thorne Berbercap Berberine

Thorne Research is one of the most trusted wellness companies in the industry. It is used by athletes and trusted sports professionals, including 11 USA Olympic teams.

You’re guaranteed to improve your blood sugar metabolism and maintain a healthy weight. It promotes healthy insulin and cholesterol levels.

It supports a healthy heart, promotes weight management, and provides GI (gastrointestinal) and immune support. It helps to promote healthy cholesterol and maintain healthy insulin levels.

This capsule supports a healthy microbial balance in the gut. It’s free from eggs, gluten, tree nuts, shellfish, peanuts, dairy, and soy. There are no unnecessary fillers and additives.

Berberine reduces the levels of lipids (fat) and glucose (sugar) in the blood through multiple mechanisms, including the modulation of the Gastrointestinal Microbiota (GM) composition. Gastrointestinal Microbiota is another name for your gut flora—the bacteria in your gut responsible for digestion and immune response.

It’s also known to prevent the abundant growth of harmful bacteria in your gut that cause bloating, IBS, and other symptoms. Most of these bacteria reside in the large intestine.

As a result, the berberine helps to reduce flatulence and bloating. It also promotes the absorption of nutrients in the gut so you get more vitamins from your food.

The effects of berberine on intestinal health include a reduction in body weight, stable blood glucose levels, and a reduction of inflammation. It also aids in treating diabetes.

A $25 bottle contains 60 capsules, of which you take 1-2 per day.

If you’re still not convinced about the quality of this product, Thorne Research is the only supplement manufacturer that collaborates with the MAYO Clinic on wellness and research content.


  • Gluten-free.
  •   Magnesium stearate-free.
  •   No added additives or fillers.
  •   One of the most trusted wellness companies in the industry.
  •   Supports a healthy microbial balance in the gut.


  • It may cause constipation in some


  •  Berberine HCL, from the root of the Berberis aristata (tree turmeric)
  • The capsule is made from Hypromellose, which is derived from cellulose, a vegetarian alternative to animal gluten
  •   Calcium Laurate: used as an anti-caking agent in capsules


If you’re looking for a holistic approach to manage your diabetes, lower the levels of high cholesterol and other fats in your bloodstream, it will greatly benefit your overall health to take berberine.

There are many amazing and reputable berberine supplements on the market. Each has something really worthwhile to offer. Select the supplement that best suits your circumstance.

Regardless of the budget differences, the dosage amounts, and the brand, the natural substance, known as berberine is an essential addition to your health journey.

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