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Finding the best berberine supplement could be the key to improving your overall mental and physical health. Berberine has been used to treat obesity, diabetes, and metabolic syndrome diseases.

Plants containing berberine have long been used in traditional medicines and treatments across the world.

Best Berberine Supplements (Our Review)

1. Nuzena – Berberine Pure +

Nuzena Berberine Pure is one of the top-rated, potent berberine supplements on the market today.

It’s also one of the most powerful options. It has 1200 mg of berberine extract per two-capsule serving.

Nuzena Berberine Pure + supplement is an excellent value-for-money supplement. It’s affordable and proven to be a quality product. 

For around $40, you’ll receive a 60-day supply of the supplement delivered straight to your door.

It has the highest amount of pure berberine in each capsule of any other berberine supplement on our list.

Taking two capsules daily will contribute to a healthy and more active metabolism.

If you’re looking to start taking berberine supplement with no added filler ingredients, then Nuzena Berberine Pure + is the best option for you. 

There are no unnecessary ingredients in this formula.

It’s designed to lower your cholesterol levels, increase metabolism, promote cardiovascular health, and support healthy blood sugar levels, among a list of other health benefits.

You will benefit the most from berberine supplements if you suffer from type two diabetes that leads to metabolic syndrome.

Research has shown that Berberine lowers glucose levels and provides healthy glucose metabolism in diabetics, which helps to regulate blood sugar control.

Taking berberine also helps to activate the Kinase enzyme. This enzyme is sometimes referred to as the “metabolic master switch.” It’s found in the cells of a variety of organs, including the brain, kidney, muscles, liver, and heart. Kinases play a huge role in regulating your metabolism.

By regulating your metabolic activity, kinases aid in the increase of energy production. This leads to better function of your organs and digesting foods in a healthy diet.

Cells repair easier which makes it particularly useful for athletes recovering from sports injuries.

A boost in metabolism and a healthy diet also means you burn more calories, which will help Nuzena Berberine Pure helps you lose weight and supports a slimmer waist. This will also work on the brown adipose tissue levels within your body.

Compared to other berberine supplements, this one is the best of the best.

Berberine Supplement
Berberine Capsules


  • Pure berberine, with no added ingredients.
  • Great for overall health
  • Value for money
  • 600mg of pure and concentrated berberine per capsule
  • Gluten-free and vegan-friendly


  • If you have any underlying conditions, consult your doctor before taking this product


  • Berberine

2. Peak Performance – GlucoVantage Super Berberine 

Compared to most berberine supplements, Super Berberine is highly absorbable and 5X more bioavailable. It is the first commercial brand that is an active metabolite of berberine and one of our top preferred berberine supplements.

In comparison to other best berberine supplements, it is 2X longer-lasting.

It’s linked to lower GI stress compared to regular berberine. It has been shown to lower sugar and glucose levels and insulin resistance sensitivity.

It’s vegan and allergy-free. There’s no soy, milk, corn, shellfish, peanuts, or wheat. It contains no gluten or preservatives. It’s also Keto-friendly and plant-based.

Whatever diet you’re on, or whatever foods you’re restricted from eating, odds are that GlucoVantage will be safe for you.

It contains DHB (Dihydroberberine) which is a metabolite of berberine. This ensures that the supplement absorbs faster and more potently.

DHB has significantly greater functional and health benefits. It inhibits fat cell growth and insulin resistance sensitivity. This helps your body respond to carbs and insulin response better.

The DHB forces the carbs you eat to be stored in your muscles as glycogen. This in turn is used by your body as energy, instead of storing it away as fat.

Regardless of your gender, if you’re seeking to lose weight and improve your insulin sensitivity, then this product is for you. It has been proven to be an effective way to lose weight with this supplement.

Berberine has been shown to aid in the reduction of the appetite-stimulating hormone leptin. This means you’ll be getting hungry less often and, in return, eating less.

Taking a berberine supplement over three months has shown significant ways to support weight loss.

As with most berberine supplements, this bottle contains 30 capsules. You can take one or two servings a day before a meal. Each capsule is 100 mg of berberine extract.


  • Linked to lower GI stress
  • Vegan friendly. Allergy-free. No preservatives
  • Highly absorbable
  • Bioavailable
  • 2x Longer lasting than regular berberine


  • Might clash with certain medications. Check with your medical practitioner before taking this supplement


  • Berberine
  • Vegetable cellulose: Great source of fiber, this has no known side effects. It has a gel-like consistency and is all-natural. It’s used to make the capsule and is easily digestible
  • Cellulose capsule: this is an anti-caking substance that helps the berberine powder flow in the capsule

3. Alive By Science – LIPO Berberine

This brand of highly concentrated non-powdered liposomal berberine comes in 150 mg capsules.

There are 90 capsules per bottle, providing a three-month supply for just under $50. These easy-to-swallow capsules boast superior absorption before reaching your stomach.

An enteric coating protects the ingredients from breaking down in the stomach and intestines so the berberine is delivered where it’s needed most.

It also increases blood circulation, which ensures a continuous flow throughout your body, allowing every organ to function properly and any wounds to heal faster.

The berberine supplements can be taken with or without food, once a day.

This non-powdered liposomal berberine capsule helps you lose weight and regulates blood sugar control and insulin metabolism.

One of the main functions of the liposomal berberine supplement activates an enzyme called AMPK, which regulates your metabolism.

The Alive by Science lipo berberine supplement also slows down the accumulation of depleted cells by inducing autophagy.

Autophagy is your body’s way of cleaning out damaged, dysfunctional, and toxic cells and proteins.

It is an evolutionary self-preservation mechanism that we developed to combat the effects of these toxic cells and proteins, which lead to chronic diseases and other age-related illnesses.

The berberine supplements contain microcrystalline cellulose, which is refined wood pulp, and slippery elm bark, which is used in vitamin supplements and tablets as a bulking agent or anti-caking agent.

Approved by science, powdered liposomal berberine is also responsible for increasing your metabolism by increasing and regulating the molecules that maintain the epigenome.

These are chemical compounds and proteins that attach to your DNA. Berberine supplementation is beneficial for your overall health and well-being.


  • Affordable
  • Reduces liver toxicity
  • Improves maximum nutrient absorption
  • Supports weight loss
  • Targeted and Advanced absorption


  • Not be suitable for people with a sensitive stomach. May cause gastric upset.


  • Berberine
  • Rice Flour: used as an anti-caking substance in a capsule.
  • Vegetable Cellulose (capsule): an essential dietary nutrient and used as an alternative to animal-sourced gluten. It is easily absorbable and has no side effects.
  • Microcrystalline Cellulose: refined wood pulp, that is used in vitamin supplements and tablets as a bulking agent or anti-caking agent.

4. Healthy Directions Clinical Grade Berberine 1500mg

These clinically graded, best berberine supplements are highly recommended by the world-renowned Dr. Whitaker, founder of the Whitaker Wellness Clinic. 

The berberine is contained in capsules of 500 mg, which are to be taken three times a day to reach the recommended dose of 1500 mg per day. For the best results, take these capsules with a meal to get the maximum results.

The berberine supplements containers come with 90 capsules for a 30-day supply of berberine.

A full berberine dosage (1500 mg a day) has been shown to support a healthy glucose response. Taken daily the berberine supplements ensure your blood glucose levels remain in the normal range.

Patients with high cholesterol levels and blood triglycerides who take at least 1000 mg of berberine a day were shown to be healthier overall, with their triglycerides and high cholesterol levels greatly improved.

The Mayo Clinic adds that green tea extract may lower LDL cholesterol.

For those suffering from type two diabetes, the best berberine supplements are safe and well-tolerated by most people.

Its powerful properties help to regulate blood sugar levels, which can fluctuate throughout the day. If not treated properly, this could lead to serious organ damage and other health issues.

The ingredients of your medication can clash with berberine supplements. Consult your healthcare provider before starting this supplement.

Research has shown that a berberine supplement can be as effective at stabilizing and regulating blood sugar levels as some conventional diabetic medication.

This is great, especially if you aren’t able to take diabetes medication due to serious health conditions, such as heart, liver, or kidney disease.


  • Contains 1500 mg of Berberine daily for advanced maintenance and health benefits
  • Formulated by an expert in the field of integrative and preventive medicine.
  • Clinically validated ingredients


  • Cannot be used if you have a serious medical condition and use any of the medications. 


  • Berberine HCl

5. Thorne Berbercap Berberine

Thorne Research is one of the most trusted wellness companies in the industry. It is used by athletes and trusted sports professionals, including 11 USA Olympic teams.

You’re guaranteed to improve and regulate blood sugar levels and support healthy blood sugar control, as well as high glucose metabolism with a healthy weight.

It promotes healthy insulin balance and cholesterol levels.

Berberine supplements support a healthy heart, promote weight management, and provide GI (gastrointestinal) and immune support. It helps to promote healthy cholesterol levels and maintain healthy insulin levels.

Thorne Research berberine combines with HCl — a potent way of taking berberine. They extract their berberine from Indian barberry root (a species of Berberis) which then undergoes four rounds of testing to ensure that you’re receiving a clean product.

This capsule supports a healthy microbial balance in the gut. It’s free from eggs, gluten, tree nuts, shellfish, peanuts, dairy, and soy. There are no unnecessary fillers and additives.

The best berberine supplements regulate the levels of lipids (fat) and glucose (sugar) and healthy blood sugar levels and blood sugar support in the blood through multiple mechanisms, including the modulation of the Gastrointestinal Microbiota (GM) composition.

Gastrointestinal Microbiota is another name for your gut flora—the bacteria in your gut responsible for digestion, gut health, immune response.

It’s also known to prevent the abundant growth of harmful bacteria in your gut that cause bloating, IBS, and other symptoms. Most of these bacteria reside in the large intestine.

As a result, the berberine supplement helps to reduce flatulence and bloating. It also promotes the absorption of nutrients in the gut so you get more vitamins from your food.

Berberine benefits derive from the root of the Berberis aristata (tree turmeric). Other berberine supplements as well as this one claim that the effects of a berberine supplement on intestinal health include a variety of benefits.

These include reduction in body weight, stable blood pressure, improved cardiovascular health, a good amount of blood glucose in your system, and a reduction of inflammation. It also aids in treating diabetes.

A $25 bottle contains 60 capsules, of which you take 1-2 per day.

If you’re still not convinced about the quality of this product, Thorne Research is the only supplement manufacturer that collaborates with the Mayo Clinic on wellness and research content.


  • Gluten-free.
  •   Magnesium stearate-free.
  •   No added additives or fillers.
  •   One of the most trusted wellness companies in the industry.
  •   Supports a healthy microbial balance in the gut.


  • It may cause constipation in some


  •  Berberine HCL, from the root of the Berberis aristata (tree turmeric)
  • The capsule is made from Hypromellose, which is derived from cellulose, a vegetarian alternative to animal gluten
  •   Calcium Laurate: used as an anti-caking agent in capsules

What is Berberine? What it’s The Benefits?

Berberine supplements claim to treat inflammatory disorders, wounds, skin diseases, to reduce fevers, eye health, tumors, and digestive and respiratory diseases.

Some of the key nutritional and health benefits include maintaining healthy cholesterol and lowering blood sugar levels, promoting cardiovascular health, regulating blood sugar levels, promoting GI microbial balance, and supporting a healthy metabolism and stable blood pressure.

According to the Memorial Sloan Kettering Cancer Center, berberine is particularly helpful to individuals with cholesterol issues who cannot use statin drugs or statin medication. Is Berberine safe to take with statin medication? Yes, it is. However, as with any medication, it is best to speak with a doctor before adding a supplement.

Taking berberine activates the AMP-activated protein called a kinase. Kinase assists in the regulation of blood sugar levels. By activating this enzyme berberine helps to treat diabetes and other health-related issues you might be dealing with, such as high cholesterol and obesity.

Taking berberine can be used to fight against a variety of chronic diseases, such as Inflammatory Bowel Disease, Alzheimer’s disease, rheumatoid arthritis, and cardiovascular diseases, this is due to its multiple-target effect.

Most berberine supplements offer a blended formula containing things like berberine hydrochloride extract for extended health benefits such as a pill that regulates blood sugar levels or a weight loss blend that includes caffeine and other supplementary ingredients.

As a positive effect of berberine’s success for weight loss, this substance also helps with fatty liver disease, affecting millions worldwide.

Using berberine could reduce the amount of fat that builds up in the liver that usually causes fatty liver disease, which would prevent the individual from developing fatty liver disease.

A study found that berberine increases insulin sensitivity, reducing insulin resistance. That same review found that berberine also lowers hba1c, or glycated hemoglobin — a marker of excessive blood sugar levels.

Adding a doctor-formulated berberine supplement to your diet is essential in maintaining a healthy and energized body.

Let’s have a look at which berberine supplement works best for you.


If you’re looking for a holistic approach to manage your diabetes, lower high HDL cholesterol levels, and other fats in your bloodstream, it will greatly benefit your overall health to take a berberine supplement.

There are many amazing and reputable berberine supplements on the market. Each has something really worthwhile to offer. Select the supplement that best suits your circumstance.

Regardless of the budget differences, the berberine dosage amounts, and the brand, the natural substance, known as berberine is an essential addition to your health journey.

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