Best Prebiotic and Probiotic Combination

The world of probiotics is like a rabbit hole and you are Alice In Wonderland. It can feel daunting, but we’re here to ease that discomfort by reviewing the best prebiotic and probiotic combination supplements, also known as synbiotics, to boost your health.

These products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. This article should only be used as a guide along with the options discussed in it with your healthcare professional.

What Are Prebiotics?

Prebiotics are nondigestible carbohydrates and plant fibers that aid in the growth of bacteria. They work as a sort of fertilizer, encouraging the growth of beneficial microorganisms in your stomach.

Many fruits and vegetables contain prebiotics, particularly those high in carbohydrates (carbs) like fiber and starch. Because these carbs can’t be digested by your body, they pass through the digestive system and become food for bacteria and other organisms like helpful yeasts such as Saccharomyces boulardii

These yeasts are also helpful in supporting gut flora and can have good utility in certain probiotics and prebiotics for this reason.

What Are Probiotics?

Probiotics vary from other supplements in that they contain living organisms, usually specific strains of good bacteria that directly contribute to the population of beneficial bacteria in your gut. 

Probiotics, like prebiotics, can be obtained from both diet and artificial supplementation that we discuss in this article. Yogurt is probably the most prevalent probiotic food and serves as a good example of what probiotics can look like.

5 Best Prebiotic and Probiotic Combinations (Our Reviews)

We extensively reviewed numerous prebiotic and probiotic products to find what we believe are the best combination supplements on the market. 

The Best Overall Pre + Probiotic had to be Seed DS-01 Daily Synbiotic. This is because it is excellent value for money, the probiotic strains in this product have been demonstrated to improve gut health. Its prebiotic component aids in the growth of beneficial bacteria and improve their overall efficacy. 

But what’s particularly brilliant about this product is how personalized it is as they can do a test on your stool to assess your gut health and make better recommendations for you. It also feels like this because they also give you a personalized list of recommended foods to eat (and avoid), chosen from over 400 foods to support your gut health.

An alternative probiotic-prebiotic supplement that came close to winning our favorite was Viome Precision Prebiotics + Probiotics. It is also value for money and its probiotic strains have been demonstrated to improve gut health. 

It stands out from its competitors because its formulation does not stop only at targeting gut health, but has probiotics that are also beneficial to skin and heart health. The experience is also different as in the first month they give you a welcome kit with a refillable glass jar among other goodies and in the months following they deliver sustainable refills.

The rest of the probiotic-prebiotic supplements and their details are below.

1. Seed – DS-01 Daily Synbiotic

The first of its kind, the DS-01™ includes clinically and scientifically studied probiotic strains that deliver core benefits to the gastrointestinal system which, in turn, influence systemic health. It also has benefits for improving your gut function, skin health, heart health, and immune function. 

It is important to note that this product requires a monthly subscription as the company believes that probiotics and prebiotics, alongside a healthy diet, balanced nutrition, exercise, and lifestyle, are cornerstone tools to building foundational health. 

Clinical research shows that continuous, daily intake is the best way to get the most out of your synbiotic supplement. And by signing up for a subscription, you’ll easily be able to build the product into your routine.

Its proprietary blend contains 16 probiotic strains including, but not limited to Lactiplanti Bacillus plantarum SD-LP1-IT, Lactobacillus rhamnosus SD-LR6-IT, Bifidobacterium lactis SD-BS5-IT, Bifidobacterium lactis SD150-BE, Limos Lactobacillus fermentum SD-LF8-IT, Limos Lactobacillus reuteri RD830-FR. The prebiotic component comes from Indian pomegranate.

Many people feel results in as little as 24-48 hours due to localized benefits like digestive health support. Other long-term benefits like cardiovascular health and gut immune function may take longer, or you may not notice anything at all. That’s completely normal. As long as you continue your daily intake, those beneficial bacteria are doing their part to sustain and enhance your health.

Seed DS-01 Daily Synbiotic is free from dairy, gluten, soy, nuts, shellfish, sesame, preservatives, and 14 classes of common allergens defined by the European Food and Safety Authority (EFSA).


  • Enhances intestinal health
  • Reduces bloating
  • Promotes proper stool hydration
  • Aids in gastrointestinal comfort


  • Is a bit expensive
  • Can cause breakouts and rashes 

2. BiomeMD – Breakthrough Digestive Care

BiomeMD is formulated by doctors who came up with a groundbreaking formula offering an essential combination of crucial, proprietary probiotics plus prebiotics. It is carefully formulated to include the prebiotic fibers only utilized by the beneficial probiotic strains you need.

It is clinically tested and proven to promote health and function of the digestive tract as well as helping to boost immune function. It also promotes better digestion and nutrient absorption means you get more energy from the food you eat.

It does this by restoring the right bacteria to your gut’s microbiome while giving them the precise prebiotic nutrients they need to thrive. 

BiomeMD helps restore and maintain a strong balance of beneficial bacteria in the gut, can help to improve immune system function, weight management goals, boost nutrient absorption, and a host of other health benefits.

Its probiotic blend contains a synergistic formula of 13 powerful probiotic strains designed for digestive and immune health. It includes Bifidobacterium lactis HN019, Lactobacillus rhamnosus L08R, Lactobacillus acidophilus, Lactobacillus gasseri L22G, and more.


  • Enhances digestion and immune protection
  • Improves digestion and absorption of nutrients
  • Is a genuine gut defender
  • Actively and effectively reaches the intestines


  • Can cause gas and upset stomach
  • Many didn’t see any results

3. The Nue Co – Prebiotic + Probiotic

Nue Co Prebiotic + Probiotic is considered a synbiotic supplement because it contains both prebiotics and probiotics. If you consider probiotic bacteria to be a seed, prebiotics are a fertilizer because they stimulate the good bacteria to grow and reproduce, giving them the best chance of survival in your gut.

It employs vegan delayed-release capsules that are free of gelatin and plasticizers. This provides an additional layer of protection against stomach acid without the requirement for acid-resistant characteristics to be substantially treated during production.

This supplement comprises of spores rather than live bacteria. According to The Nue Co, this means that the 15 billion spores per dose do not begin to operate until they reach your small intestine, giving them a better chance of survival as they go through your body. 

There are a couple of reasons for this. The first is that these spores lie dormant until they’re activated in your small intestine and it’s room-temperature stable, so no refrigeration is necessary.

Once the spores activate in your small intestine, they begin to multiply, creating more and more good bacteria. The strain that they use, Bacillus coagulans, has been proven to work well for those suffering from irritable bowel syndrome (IBS). 

These twice-daily pills include probiotic bacteria (the probiotic lactospore powder has Bacillus coagulans) as well as prebiotic organic inulin fiber (a type of plant fiber) from Jerusalem artichoke, which aids digestion and reduces bloating. 


  • Improves gut health
  • Significantly improves overall body health
  • Vegan


  • Can cause an upset stomach

4. Viome – Precision Prebiotics + Probiotics 

Viome uses the results from processing your personal test samples, in combination with their robust AI platform, to formulate the strains of probiotics that will be most beneficial to your gut health.

Each Precision Supplements formula is unique because their product supports healthy digestion, immunity, and more with a probiotic formula made for you. 

Since their formula is chosen with intention, their dosages are refined with precision. They deliver a 30-day supply of your customized prebiotics and probiotics, delivered monthly.

They will also deliver you a customized list of superfoods and foods to avoid to help you optimize your gut health. 

Using this list will improve the richness and diversity of your gut environment. It will fuel the gut bacteria which in turn helps your overall gut health; will help minimize foods that may be harmful to your health, and reduce foods that can increase your blood sugar levels. 

Viome Precision Prebiotics + Probiotics contains the following probiotic blend and more: Lactobacillus plantarum, Lactobacillus gasseri, Bacillus coagulans, Lactobacillus acidophilus, Lactobacillus reuteri, and Lactobacillus rhamnosus. The prebiotics used are fruit sugars (fructooligosaccharides) and inulin (a type of fiber).

Their product is allergen-free which refers to products that are free of the current top 8 allergens as recognized by the Food and Drug Administration. Those allergens are dairy, wheat, eggs, soy, shellfish, fish, tree nuts (including coconut), and peanuts. So if you have any common food allergies, you can rest easy that this supplement will work for you.


  • Improves gut health
  • Is easy to use
  • Improves overall health
  • Increases energy levels


  • Some have not seen results
  • Cost of product is high

5. GundryMD – Bio Complete 3 Dietary Supplement


Bio Complete 3 works to support easier digestion, better weight management, more energy, fewer unhealthy cravings, and improved muscle strength by using what they call the “3-Pronged Defense” to gut health:

  1. Boost your probiotic levels, so you have an abundance of good gut bacteria
  2. Boost your prebiotic levels, so your good gut bacteria have the proper fuel to thrive
  3. Boost butyrate (a.k.a. postbiotic) levels, so you can achieve an ironclad gut lining (and help combat issues of leaky gut like low energy and cravings for unhealthy food)

Simply take two small capsules twice per day, preferably before a meal. Bio Complete 3 has been formulated to be ultra-fast absorbing — so it can go right to work in your gut — resulting in a boost in energy you can truly feel.

Bio Complete 3 can help you enjoy a slimmer waistline, reduce cravings for unhealthy food, and even give you more energy. Every individual is unique and results may vary.

Most users report feeling noticeably smoother digestion and fewer cravings along with an increase in energy, vitality, and muscle strength in their first week of use. However, the most dramatic results were reported after consistent use over the course of 4 weeks and beyond.

It has the probiotic strain Bacillus coagulans and prebiotics from sunfiber and CoreBiome tributyrin.


  • Assists with weight loss
  • Gives you energy
  • Improves digestive health
  • Lowers food cravings


  • Pricey
  • Can cause bloating and discomfort

Prebiotic and Probiotic Combination Supplements FAQs

What are the effects of using a prebiotic and probiotic together (synbiotics)?

Synbiotics play a significant role in gut health and the prevention of illness by preserving normal gut flora and promoting the growth of helpful bacteria that inhibit the growth of bad bacteria.

What are the uses of synbiotics?

There is evidence that prebiotics and probiotics combined assist to reduce allergic disorders in pregnant women and their children. An increase in Bifidobacteria and Lactobacilli numbers in feces is good news as they are signs of limiting the growth of bad bacteria.

How safe are synbiotics?

The combination of prebiotics and probiotics appears to be safe for infants and children, with no known side effects. More research, however, is needed to corroborate these findings.
It’s always advised that you speak to your doctor before starting a new regimen of supplements, no matter the reason.

What is the dosage for synbiotics?

It is preferable to begin with a low dose of synbiotics and gradually increase your dosage to determine your tolerance.

While there are relatively few side effects of synbiotics, it’s possible that you may be allergic to one of the ingredients, so you should err on the side of caution.

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