David Sinclair might be 52 years old, but he sure doesn’t look it. In fact, the Australian biologist has been studying why we age and how to slow it down for years.

So, what’s his secret to looking straight out of the Fountain of Youth? We’ve dove into the lengthy list of David Sinclair supplements to find out.

Read on to discover Sinclair’s daily supplement regimen.

David Sinclair’s Supplement Stack


Resveratrol is a naturally occurring compound that can be found in peanuts, Japanese knotweed, blueberries, and in the skin of red grapes. Resveratrol contains antioxidants.

Resveratrol is widely available as a dietary supplement made from the extracts of Japanese knotweed, red wine, and grape seeds. It is also one of the main ingredients in Relief Factor, a popular anti-inflammatory supplement.

Sinclair once said of Resveratrol…

“(It’s) as close to a miraculous molecule as you can find…. One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer.” (source).

The claimed benefits of Resveratrol are:

  • Promotes youthful gene expression similar to calorie-restricted diets
  • Supports healthy insulin response & mitochondrial function
  • Helps maintain already-healthy glucose levels
  • Supports a healthy inflammatory response & helps inhibit oxidation

Nicotinamide Mononucleotide

Every morning, David Sinclair takes 1 gram of Nicotinamide Mononucleotide (NMN), often mixed in his yogurt. While Sinclair never shares brand names, we recommended Peak Performance NMN Supplement + Resveratrol or California Gold Nutrition Nicotinamide Mononucleotide.

When combined, Nicotinamide Mononucleotide and Resvaqeratrol are said to promote longevity and healthy aging, support cardiovascular health, and increase NAD+ production, which is key to supporting a healthy metabolism.

All of that being said, it’s no wonder why Sinclair takes this supplement daily.


Metformin is a diabetes drug that’s currently being studied for its anti-aging effects. David Sinclair takes 500 mg of this prescription drug in the morning and 500 mg in the evening, adding up to 1 gram daily.

Since Metformin can only be obtained through a prescription, you must first consult with your doctor if you want to add this supplement to your daily routine.

Metformin is recommended for those with type 2 diabetes and should not be taken by anyone over 65 years old.

Vitamin D3

Although David Sinclair has said he aims to get most of his daily vitamins from his diets, he does take a few vitamin supplements as a part of his morning routine, one being vitamin D3.

This vitamin is said to be able to extend lifespan as well as reduce the risk of various aging-related diseases. While it’s unknown what brand of vitamin D Sinclair takes, but we recommended California Gold Nutrition’s Vitamin D3.

You could also look at a multivitamin for men.

Vitamin K2

Vitamin K2 offers a plethora of benefits including a strengthening of bone health, vascular and mitochondrial health, and an improvement in skin appearance.

Every day, David Sinclair incorporates vitamin K2 into his supplement super stack so he can enhance its benefits within his body. Although he hasn’t mentioned a specific brand, we recommended Life Extension’s Mega Vitamin K2.


Statin is a prescription drug that is known for its protection against cardiovascular disease. Sinclair has taken this drug since his early 20s, as there is a history of cardiovascular disease within his family.

Statin can lower your cholesterol by blocking a substance your body needs to make cholesterol. As a result, the drug is said to reduce illness and mortality among those who are at high risk of cardiovascular disease.

While this drug may seem appealing to you, it’s required that you talk to a doctor about this supplement in order to get the go-ahead on the prescription.


Every morning, David Sinclair takes 83 mg of Aspirin, and for a good reason. Taking a low dose of Aspirin each morning can reduce inflammation, reduce the risk of heart attacks, and even the risk of cancer.

With David Sinclair’s history of cardiovascular disease in his family, it makes sense as to why he would choose to incorporate this into his daily routine. As for what brand of Aspirin to take, we recommended Life Extension Low Dose Aspirin.

Alpha Lipoic Acid

Alpha Lipoic Acid is an antioxidant that can be found in yeast, liver, kidney, spinach, broccoli, and potatoes. While this might be enough for some, David Sinclair boosts his daily Alpha Lipoic Acid intake by taking it as a supplement.

Alpha Lipoic Acid has been shown to prevent nerve pain in people with diabetes, lower total cholesterol and low-density lipoprotein in the body, and prevent obesity. For best results, we recommended taking California Gold Nutrition Alpha Lipoic Acid daily.

Coenzyme Q10

David Sinclair pairs his daily Statin medication with Coenzyme Q10, as CoQ-10 apparently replenishes what statin medications may deplete. This supplement is said to support cardiovascular health, thus promoting a longer lifespan.

If you plan on incorporating this supplement into your daily diet, we recommend choosing Lake Avenue Nutrition CoQ10, as it’s made with natural ingredients and has been clinically studied.

So, you wanted to know what supplements David Sinclair takes as part of his attack on aging. We’ve given you a full list of David Sinclair supplements, which will you be adding to your stack first?

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