OverviewDosageSide EffectsInteractionsHalf-Life

Prozac and alcohol interactions can occur, which is why patients should avoid alcohol use during treatment with this medication.

Side Effects

Fluoxetine is the generic name for many brand-name selective serotonin reuptake inhibitors (SSRIs), including Prozac. When mixing fluoxetine with alcohol, patients can experience side effects like:

  • Counteraction or exacerbation of anxiety and/or depression symptoms
  • Interactions-—including heightened blood pressure—with any additional medications you take, such as monoamine oxidase inhibitors (MAOIs)
  • Drowsiness
  • An increased risk of alcohol abuse
  • Difficulty sleeping or insomnia


Fluoxetine and alcohol interactions are effectively the result of synergistic actions. In other words, these medications can enhance each other’s side effects, resulting in symptoms like enhanced drowsiness.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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