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There is some indication that drinking alcohol might affect those on valacyclovir. There are side effects with this drug, and alcohol can enhance them. 

Side Effects

It is possible that drinking alcohol while taking valacyclovir might worsen side effects like depression, irritability, and fatigue. Some also experience reduced mental alertness and flu-like symptoms with this drug. 

Interactions

Alcohol tends to make the side effects of most medications worse. This tendency is true with valacyclovir, as well.

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