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While there are not reported to be major interactions between Vyvanse and alcohol, serious interactions can occur if the patient is simultaneously taking methotrexate [Otrexup (PF), Xatmep, Trexall]. Methotrexate is a drug used during chemotherapy. 

Side Effects

Because alcohol can cause high blood pressure and so can Vyvanse, it may not be advisable to take both together. High blood pressure (hypertension) is perhaps the single-most common side effect of Vyvanse. For more information, please refer to our page on Vyvanse side effects.


There are no specific interactions between this drug and alcohol listed by the FDA or drug manufacturer. That said, there are always concerns when mixing alcohol with any medication. For example, one study indicates it may cause a dangerous rise in blood pressure and heart rate.

Unfortunately, overdose risk is also a potential complication of mixing these two substances. Specifically, Vyvanse can suppress some of the side effects of drinking like sleepiness. Someone taking Vyvanse therefore may not realize how much alcohol they are drinking and accidentally overdose.

Always discuss your medications with your physician before consuming any alcohol.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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