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There are a variety of alternative medications available that treat nerve pain and/or seizures. Your doctor will be able to determine the best medication for your specific health needs. If gabapentin does not work for you, or if you believe the side effects are too severe, talk with your doctor to find an alternative medicine to treat nerve pain and/or seizures.


Certain antidepressants work to relieve pain. Your doctor may prescribe you an antidepressant instead of a GABA analogue, like gabapentin, to treat pain, based on your individual health profile.

According to Harvard Health, these medications include:

  • Tricyclic antidepressants, including amitriptyline (Elavil)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs), including duloxetine (Cymbalta)

Alternative Therapies

Some people, alongside the guidance of their doctor, may decide to seek treatment without medication. Or, they may choose to adopt additional therapeutic techniques while taking medication to relieve nerve pain. Such therapies may include:

  • Water aerobics: Exercise is a crucial aspect of maintaining good health, but it can feel impossible for people with chronic pain. Water aerobics can be a form of hydrotherapy, where people find relief through water exercises. A 2019 study concluded that water therapy can have positive affects on pain, fatigue and quality of life for people with fibromyalgia syndrome (FMS).
  • Acupuncture: Acupuncture is a common technique used to treat all kinds of pain, including arthritis, back pain, and even headaches. There are some risks, so make sure to talk with your doctor before deciding to seek acupuncture treatment.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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