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Baclofen vs. Flexeril: what is the difference? Both of these drugs are commonly prescribed to treat muscle spasms, although Flexeril may have more limited use than baclofen.  


Baclofen works by inhibiting reflexes at the spine and some in the brain, which has a relaxing effect. 


Spasticity from Multiple sclerosis or spinal injury are common indications with baclofen. It is also used to control hiccups and muscle spasms in those at the end of life. 


  • Hypersensitive to baclofen
  • Poorly tolerated by stroke victims
  • May exacerbate mental health disorders such as schizophrenia.
  • May exacerbate autonomic dysreflexia, the sudden onset of high blood pressure.
  • May exacerbate epilepsy


Flexeril (cyclobenzaprine) is a medication prescribed to treat muscle spasms as well. It is only recommended for short-term use. Flexeril works by blocking certain nerve impulses at the brain stem.  


Common indications with Flexeril include:

  • Muscle spasms related to injury
  • Muscle spasms related to illnesses such as MS


  • Thyroid disorder
  • Heart block
  • Heart rhythm disorder
  • Congestive heart failure
  • Recent heart attack

Baclofen vs. Flexeril – What is the Difference?

Both of these drugs likely work in similar ways to control muscle spasms. but they act on different parts of the central nervous system. Flexeril is a commonly prescribed medication for muscle or skeletal injury. It works by blocking certain nerve impulses at the brain stem. Baclofen works on both the spine and on receptors in the brain. In addition, Flexeril is only for short-term use. Talk to your doctor about the best option for your medical needs.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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