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Below are the general guidelines for lisinopril dosage. Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking lisinopril.

The following information comes from DailyMed, an FDA-approved website providing drug label information.

Usual Adult Dose for:

Hypertension

Initial Therapy in adults: The recommended initial dose is 5 to 10 mg once a day. Dosage should be adjusted according to blood pressure response by your physician. The usual dosage range is 20 to 40 mg per day administered in a single daily dose (some patients may take twice a day depending upon physician). Doses up to 80 mg have been used but do not appear to give greater effect. It is important to take lisinopril every day even if your blood pressure is not elevated. It is not an as needed medication. (if your blood pressure is very low then do not take lisinopril or other blood pressure medication (90 mm Hg/ 60 mm Hg or less))

Use with diuretics in adults

If blood pressure is not controlled with lisinopril alone, a low dose of a diuretic may be added (e.g., hydrochlorothiazide, 12.5 mg). After the addition of a diuretic, it may be possible to reduce the dose of lisinopril.

The recommended starting dose in adult patients with hypertension taking diuretics is 5 mg once per day.

Pediatric Patients 6 years of age and older with hypertension

For pediatric patients with glomerular filtration rate (kidney function) > 30 mL/min/1.73 m^2, the recommended starting dose is 0.07 mg per kg once daily (up to 5 mg total). Dosage should be adjusted according to blood pressure response up to a maximum of 0.61 mg per kg (up to 40 mg) once daily. Doses above 0.61 mg per kg (or in excess of 40 mg) have not been studied in pediatric patients.

Lisinopril is not recommended in pediatric patients < 6 years or in pediatric patients with glomerular filtration rate (kidney function) < 30 mL/min/1.73 m^2.

Heart Failure

The recommended starting dose for lisinopril, when used with diuretics and (usually) digitalis as adjunctive therapy for systolic heart failure, is 5 mg once daily. The recommended starting dose in these patients with hyponatremia ( lower serum sodium < 130 mEq/L) is 2.5 mg once daily. Increase as tolerated to a maximum of 40 mg once daily.

Diuretic dose may need to be adjusted to help minimize hypovolemia (lowered overall volume of blood/fluid) , which may contribute to hypotension (low blood pressure) . The appearance of hypotension after the initial dose of lisinopril does not preclude subsequent careful dose titration with the drug, following effective management of the hypotension.

Reduction of Mortality in Acute Myocardial Infarction

In patients with stable blood pressure/stable blood flow (hemodynamically stable) within 24 hours of the onset of symptoms of acute myocardial infarction (heart attack), give lisinopril 5 mg orally, followed by 5 mg after 24 hours, 10 mg after 48 hours and then 10 mg once daily. Dosing should continue for at least six weeks with a max dose of 40 mg per day.

Initiate therapy with 2.5 mg in patients with a low systolic blood pressure (≤ 120 mmHg and > 100 mmHg) during the first 3 days after the infarct . If hypotension occurs (systolic blood pressure ≤ 100 mmHg) a daily maintenance dose of 5 mg may be given with temporary reductions to 2.5 mg if needed. If prolonged hypotension occurs (systolic blood pressure < 90 mmHg for more than 1 hour) lisinopril should be withdrawn.

Dose in Patients with Renal Impairment

No dose adjustment of lisinopril is required in patients with creatinine clearance > 30 mL/min. In patients with creatinine clearance ≥ 10 mL/min and ≤ 30 mL/min, reduce the initial dose of lisinopril to half of the usual recommended dose i.e., hypertension, 5 mg; systolic heart failure, 2.5 mg and acute MI, 2.5 mg. Up titrate as tolerated to a maximum of 40 mg daily. For patients on hemodialysis or creatinine clearance < 10 mL/min, the recommended initial dose is 2.5 mg once daily.

What if I miss a dose of Lisinopril?

If you miss a dose of lisinopril, take it as soon as possible, unless you are closer to your next day’s dose. In that case, skip the missed dose and wait until the next one.

What if I overdose on Lisinopril?

If you have overdosed on lisinopril, call for medical help immediately. Lisinopril can be removed through kidney dialysis, otherwise known as hemodialysis. Overdosing on an ACE-inhibitor, like lisinopril, can result in hypotension. In severe cases, overdosing can be fatal.

How is Lisinopril administered?

Lisinopril is administered orally once or twice daily. (maximum total daily dose of 40 mg per day)

How is Lisinopril supplied?

2.5 mg Tablets: white to off-white, capsule-shaped tablets, imprinted with ‘H 144’ on one side and plain on the other side.

NDC 43547-351-03 Bottles of 30 tablets

NDC 43547-351-10 Bottles of 100 tablets

NDC 43547-351-50 Bottles of 500 tablets

5 mg Tablets: yellow, capsule-shaped tablets, imprinted with ‘H 145’ on one side and plain on the other side.

NDC 43547-352-10 Bottles of 100 tablets

NDC 43547-352-11 Bottles of 1000 tablets

10 mg Tablets: light pink, capsule-shaped tablets, imprinted with ‘H 146’ on one side and plain on the other side.

NDC 43547-353-03 Bottles of 30 tablets

NDC 43547-353-10 Bottles of 100 tablets

NDC 43547-353-11 Bottles of 1000 tablets

20 mg Tablets: dark pink, capsule-shaped tablets, imprinted with ‘H 147’ on one side and plain on the other side.

NDC 43547-354-03 Bottles of 30 tablets

NDC 43547-354-10 Bottles of 100 tablets

NDC 43547-354-11 Bottles of 1000 tablets

30 mg Tablets: red, capsule-shaped tablets, imprinted with ‘H 148’ on one side and plain on the other side.

NDC 43547-355-03 Bottles of 30 tablets

NDC 43547-355-10 Bottles of 100 tablets

NDC 43547-355-50 Bottles of 500 tablets

NDC 43547-355-11 Bottles of 1000 tablets

40 mg Tablets: yellow, capsule-shaped tablets, imprinted with ‘H 149’ on one side and plain on the other side.

NDC 43547-356-10 Bottles of 100 tablets

NDC 43547-356-11 Bottles of 1000 tablets


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