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When pregnancy is detected, discontinue lisinopril as soon as possible

Lisinopril can cause fetal harm when administered to a pregnant woman. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death.

Can lisinopril cause birth defects during pregnancy?

The use of this drug during pregnancy is not advisable unless no other alternative or option is available. In these cases, both the parent and the fetus should be carefully monitored for adverse reactions. That being said, it’s still possible that risks won’t be detected until irreversible harm is done.

According to the U.S. National Library of Medicine, risks for the fetus while taking lisinopril include:

  • “reduced fetal renal function leading to anuria and renal failure,
  • fetal lung hypoplasia and skeletal deformations, including skull hypoplasia,
  • hypotension [low blood pressure], and
  • death.”

Can lisinopril cause a miscarriage?

There currently isn’t enough available data to estimate the risk of miscarriage while taking this drug. That being said, this drug may increase the risk of fetal and newborn death.

Lisinopril, Labor and Delivery

The FDA does not recommend lisinopril use during pregnancy, as it can cause injury or death to the baby, especially during the second and third trimesters.

Lisinopril and Lactation

There isn’t enough data to support the idea that taking lisinopril while breastfeeding is safe in humans. Therefore, current guidelines advise against breastfeeding with lisinopril use.

Lisinopril and Fertility

There is not enough data to say whether or not lisinopril affects human fertility. In rat studies, though, there were no noted impairments of fertility.

Is it safe to take lisinopril while pregnant?

Use of this drug while pregnant should be avoided unless no other viable alternative to control the pregnant parent’s blood pressure exists. In such rare cases, extensive monitoring of the parent and fetus should occur.


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