OverviewDosageSide EffectsInteractionsHalf-Life

Lisinopril is currently the single-most popular prescription medication in the United States, with over 104,779,318 prescriptions so far in 2020. Considering how popular this drug is, it pays to know more about it, including how long lisinopril stays in your system.

How long does lisinopril stay in your system?

Lisinopril is likely detectable in your system for the following time frames:

Urine: Roughly 3 to 4 days after last use

Saliva: N/A

Plasma: N/A

Hair: Potentially up to 90 days after last use, although accuracy may be low

(Numbers above are merely estimates, and may vary based on several factors, such as age and other medical conditions.)

Lisinopril Half-Life

Mean effective half-life: 12.6 hours

Time to steady-state: After second daily dose

Mean accumulation ratio: 1.38

Terminal phase half-life: 40 hours

Lisinopril has an oral bioavailability of 25% +/- 4% and is not metabolized but filtered by the kidneys, according to The American Journal of Medicine.

What is the half-life of lisinopril?

According to the FDA, the half-life of lisinopril (Zestril) is about 12 hours after multiple doses. That means it takes the body about 12 hours to reduce lisinopril concentrations by half. Note that it will take more than two half-lives for the body to completely eliminate this drug.

Does lisinopril last 24 hours?

Lisinopril is a once-daily (sometimes prescribed as twice daily) medication. Patients are typically closely monitored for their first few doses; physicians may then adjust doses accordingly to ensure patients’ blood pressure levels are stabilized.

Can I take lisinopril 2 times a day?

You should not take lisinopril 2 times a day, unless explicitly stated otherwise by your prescribing physician. (maximum dose per day is 40 mg)

What is the peak time for lisinopril?

According to the FDA, lisinopril reaches peak effectiveness in most adults about 6 hours after an oral dose, with peak serum concentrations occurring about 7 hours after a single dose.

Can you just stop taking lisinopril suddenly?

No; unless explicitly instructed by your doctor, you should not suddenly stop taking lisinopril. Always consult your physician before changing your dose, schedule, etc.


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