OverviewDosageSide EffectsInteractionsHalf-Life

Clobetasol propionate was the 209th most commonly prescribed drug in the United States in 2017. That year alone, there were over 2,438,775 prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long clobetasol propionate stays in your system.

Experts state the following information regarding clobetasol propionate half-life:

Mean effective half-life: Information not readily available

Terminal phase half-life: Information not readily available

Time to steady-state: Information not readily available

Mean accumulation ratio: Information not readily available

Experts predict that its bioavailability is 1. The body eliminates corticosteroids like this one mainly through urine.


What is the half-life of clobetasol propionate?

Experts are currently not 100% sure of the half-life of clobetasol propionate. However, some research examined serum cortisol levels after administration of 25 g clobetasol propionate (0.05%). Researchers found that patients’ cortisol levels were still low until 96 hours after topical treatment.

How long does clobetasol propionate stay in your system?

Since experts are unsure of the half-life of this medication, determining how long it stays in your system is tricky. Some researchers, though, found that serum cortisol levels remained low up to 96 hours after topical use of this medication. These findings suggest that clobetasol propionate can stay in the human body for extended periods of time with long-lasting effects.

Is clobetasol stronger than hydrocortisone?

Yes, clobetasol propionate is stronger than hydrocortisone.

Hydrocortisone is the medication version of the naturally occurring hormone cortisol; it is available under brand names like Hydrocort and Cortenema. Like clobetasol propionate, hydrocortisone can help treat skin conditions, although it is far less potent.

How often can you use clobetasol propionate?

Patients should never use this medication more than as directed by their doctor. While this amount is typically just once a day, some patients may be directed to apply the brand Temovate twice a day.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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