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As is the case with any other medication, there may be some instances where Entyvio interactions can occur. In such cases, use is not recommended or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with Entyvio (vedolizumab) include the following:

  • Natalizumab (Tysabri)
  • Tumor necrosis factor (TNF) blockers, such as adalimumab (Humira), certolizumab (Cimzia), golimumab (Simponi), and infliximab (Remicade)
  • Live vaccines, such as nasal spray flu vaccines, rotavirus vaccines, chickenpox vaccines, and MMR (measles, mumps, rubella) vaccines

Please note that this list is NOT complete, and other interactions with drugs not listed here may occur.

Entyvio and Prednisone

There are no known interactions between Entyvio and prednisone. However, individuals should discuss the safety of taking both medications with their healthcare provider.

Vedolizumab and Azathioprine

Taking vedolizumab and azathioprine may increase the risk of infections, but more research is needed on potential interactions between these medications. A 2017 study found that a patient treated with vedolizumab, azathioprine, and methylprednisolone developed a meningitis infection involving listeria.

Vedolizumab and Adalimumab

Vedolizumab may interact with adalimumab, which is a tumor necrosis factor (TNF) inhibitor. Using both medications might raise the risk of infections avoid use.

Vedolizumab and Ustekinumab

Vedolizumab and ustekinumab, which is another biologic therapy used for Crohn’s disease, are not known to have any negative interactions. A 2017 study showed that a patient treated with both medications for 6 months did not experience any side effects.

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with Entyvio include:

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Entyvio and Alcohol

For more information, please visit our page on Entyvio and alcohol interactions.

Disease and Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases and medical conditions that are known to negatively interact with Entyvio include:

  • Infections
  • Liver disease
  • Progressive multifocal leukoencephalopathy (PML)

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Entyvio and Coronavirus

Taking Entyvio is not known to lead to a higher risk of getting the coronavirus specifically, although more research is needed. Since managing Crohn’s disease or ulcerative colitis symptoms is important, individuals should discuss their treatment plan with their healthcare provider if they have concerns about the coronavirus. Keep in mind that patients treated with this medication may have a higher risk of developing infections, including upper respiratory infections.

Entyvio and Pregnancy

For more information, please visit our page on Entyvio and pregnancy risks.

Entyvio and Hair Loss

Entyvio is not known to lead to an increased risk of hair loss. Although some individuals have experienced hair loss while being treated with Entyvio, whether or not this medication was the cause of this effect is unknown.

Entyvio and Weight Gain

Entyvio is not known to cause weight gain or an increased risk of gaining weight. Some individuals being treated with Entyvio may experience weight gain, but this is not considered a side effect of this medication.

Entyvio and Joint Pain

Joint pain might occur in those who take Entyvio. Clinical studies showed that roughly 12 percent of individuals taking Entyvio had joint pain.

Entyvio and PML (Progressive Multifocal Leukoencephalopathy)

Clinical studies do not show an association between Entyvio use and the development of PML. This viral infection affects the brain and can have serious complications, although it usually occurs in individuals with weakened immune systems. Clinical studies involving other medications used for Crohn’s disease, such as natalizumab, have shown a risk of developing PML. Individuals taking Entyvio should be watched for signs of PML as a precaution, such as weakness that affects one side of the body, confusion, problems with memory, problems with vision, and coordination problems.

Entyvio and Breastfeeding

For more information, please visit our page on Entyvio and pregnancy risks.

Vedolizumab and Arthritis

Vedolizumab has been associated with a risk of joint pain. For those who have arthritis, this medication may lead to increased joint pain, although additional research is needed. A 2017 study on the use of this medication for arthritis and inflammatory bowel disease stated that some patients treated with vedolizumab reported experiencing worsening joint pain.

Other Interactions

Other potential interactions include the following.

Entyvio and Surgery

Individuals who are having surgery should discuss the safety of continuing to receive Entyvio injections. In some cases, healthcare providers might recommend that individuals schedule surgery at a later time. This includes dental procedures, as well as medical procedures. A 2018 study showed that patients treated with vedolizumab did not experience postoperative complications after having non intestinal procedures.

Vedolizumab and Anti-Vedolizumab Antibody

For some individuals, healthcare providers might use tests to measure the serum concentration of vedolizumab and anti-vedolizumab antibodies. This is done in order to help healthcare providers make clinical decisions on treatment for Crohn’s disease and ulcerative colitis. Those who are currently taking vedolizumab and nivolumab should avoid having this test done, since it may affect results.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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