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As is the case with any other medication, there may be some instances where pregabalin interactions can occur. In such cases, use is not recommended or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with this medication include the following.

  • Oxycodone due to possible additive effects on gross motor functioning and cognitive functioning when co-administered with pregabalin
  • Lorazepam due to possible additive effects on gross motor functioning and cognitive functioning when co-administered with pregabalin
  • Ethanol due to possible additive effects on gross motor functioning and cognitive functioning when co-administered with pregabalin
  • Zolpidem
  • Pramipexole
  • Ropinirole
  • All opioids
  • All medications that cause some type of CNS depression

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Marijuana & THC

The use of pregabalin and marijuana or cannabis may increase the risk of experiencing certain side effects, such as drowsiness, trouble concentrating, and dizziness.

Gabapentin (Neuraptine)

Using gabapentin and pregabalin together may lead to increased risks of drowsiness, impaired thinking, confusion, lightheadedness, and other side effects.

Trazodone (Oleptro)

The combined use of trazodone and pregabalin might increase certain side effects, such as trouble concentrating, dizziness, judgment, and drowsiness.

Advil (Ibuprofen)

No interactions were found between Advil or ibuprofen and pregabalin. Individuals who have concerns about taking these medications together should talk to their doctor first.

Risperidone (Risperdal)

Taking pregabalin and risperidone together may raise the risk of experiencing stronger side effects, such as drowsiness, confusion, and dizziness.

Metoprolol (Lopressor)

Interactions between pregabalin and metoprolol have not been found. Those who have concerns about taking these medications together should talk to their doctor first.

Lisinopril (Qbrelis)

The use of lisinopril and pregabalin may lead to an increased risk of developing a condition called angioedema, which can cause facial swelling and swelling in the throat, lips, eyes, tongue, feet, and hands.

Topiramate (Topamax)

Using topiramate and pregabalin together might raise the risk of having stronger side effects, including dizziness, trouble concentrating, lightheadedness, and confusion.

Tramadol (ConZip, Ultram)

The use of tramadol and pregabalin together might increase the risk of experiencing serious and potentially fatal side effects, such as respiratory distress and coma, since both medications cause depressive effects in the central nervous system.

Warfarin (Jantovin)

No drug interactions have been found between pregabalin and warfarin. Individuals with concerns about taking these medications together should talk to their doctor.

Tylenol (Acetaminophen)

Taking Tylenol or acetaminophen and pregabalin together has not been found to have interactions. Those who have concerns about using these medications together should talk to their doctor.

Nortriptyline (Pamelor)

The use of nortriptyline and pregabalin might increase the severity of certain side effects, such as dizziness, confusion, and drowsiness.

Adderall

Drug interactions between pregabalin and Adderall have not been found. Those with concerns about using these medications together should talk to their doctor.

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with this drug include:

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Pregabalin and Alcohol

For more information, please visit our page on pregabalin and alcohol interactions.

Methylcobalamin (Vitamin B12)

No negative interactions between pregabalin and methylcobalamin or vitamin B12 have been found. A 2013 study found that the use of sustained-release pregabalin and methylcobalamin led to significantly reduced symptoms of neuropathic pain.

Diseases & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases and medical conditions that are known to negatively interact with pregabalin include:

  • Angioedema due to an increased risk of experiencing this condition, especially in those who already have a higher vulnerability to angioedema or those who have had it before
  • Myopathy or elevated creatine kinase levels due to a higher risk of having creatine kinase levels increase
  • Depression due to an increased risk of suicidal behavior or suicidal ideation
  • Ocular conditions due to an increased risk of experiencing blurred vision
  • Thrombocytopenia or those at risk of thrombocytopenia due to the risk of developing a low platelet count
  • Peripheral edema, especially in those with congestive heart failure or other cardiac problems
  • Conduction abnormalities in the heart due to the risk of prolonged PR intervals

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Pregabalin and Pregnancy

For more information, please visit our page on pregabalin and pregnancy risks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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