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Pregabalin (Lyrica) is approved for use in treating nerve pain and seizure disorders, but it also has off-label uses, including anxiety treatment. Pregabalin for anxiety has been shown to provide effective relief from anxiety symptoms in some individuals. A 2013 study showed that this medication provides effective short-term relief for generalized anxiety disorder. 

Pregabalin for Anxiety

The exact mechanism of action for pregabalin is not fully understood. It might provide anti-anxiety effects by causing a decrease in the activity of neurotransmitters or chemicals in the brain that are associated with anxiety, such as glutamate. This medication binds to the alpha2-delta site within the central nervous system.


Dosages for pregabalin in general range from 150 mg per day to 600 mg per day. This medication is usually taken in two or three doses per day. The recommended dosage amount for treating anxiety can vary based on certain factors, such as the severity of an individual’s anxiety symptoms. Those who are considering taking pregabalin for anxiety should follow their doctor’s recommended dosage amount.

For more information, please visit our page on pregabalin dosage.

Side Effects

Pregabalin can cause side effects ranging from mild to severe. Mild side effects may include dizziness, blurred vision, sleepiness, problems concentrating, drowsiness, dry mouth, swelling in the feet or hands, and weight gain. More serious side effects may include allergic reactions, suicidal thoughts, and heart problems, such as chest pain.

For more information, please visit our page on pregabalin side effects.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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