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Topamax is approved for use in preventing migraines and treating seizures, but it has not been approved for depression. However, Topamax and depression is considered an off-label use for this medication. Does it have a positive or negative impact on those with depression? Individuals who are considering taking this medication should learn more about its effects.

*If you experience suicidal thoughts, a symptom that may occur with this medication, seek help or call 911 immediately if you are in danger.

What is Topamax?

Topamax is an anticonvulsant prescription medication with the active ingredient topiramate. While there are no contraindications for this medication, individuals with certain conditions, such as kidney problems, might need to exercise caution while taking it.

How Does Topamax Work?

The effects that Topamax has on seizures and migraine prevention is not fully understood, although it is thought to cause certain changes in brain chemicals.

Does Topamax Have a Positive or Negative Impact on Depression?

Topamax may have positive or negative impacts on depression. A 2011 study found that Topamax helped improve depression for those who have resistant major depressive disorder. However, suicidal thoughts and behaviors are also associated with the use of Topamax in some individuals.

Final Thoughts

Those who are considering taking Topamax for depression should go over the potential adverse effects, such as suicidal thoughts and ideation, with their doctor. Topamax may be helpful for those who have not been able to find relief with other types of medication for depression.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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