OverviewDosageSide EffectsInteractionsHalf-Life

Generic Name: Buspirone

Brands: BuSpar (discontinued in the U.S.)

Class: Anti-anxiety agent or anxiolytic 

Availability: Prescription

Molecular Formula: C21H31N5O2

Substance UNII: TK65WKS8HL

What is Buspirone?

Buspirone is an anti-anxiety medication. It was sold under the trade name BuSpar, which has been discontinued in the U.S. Buspirone is still available as a prescription medication in generic form.

What is Buspirone Used For?

Buspirone is used for treating anxiety disorders or for short-term relief from anxiety symptoms. It has also shown potential effectiveness at helping ease symptoms of attention deficit hyperactivity disorder (ADHD), as well as depression in those with generalized anxiety disorder (GAD).

How Does Buspirone Work?

Buspirone is taken to provide individuals with clearer thinking, reduce irritability, and promote relaxation. The exact mechanism of action for buspirone is not known. Based on in vitro studies, buspirone has shown a tendency to interact with serotonin receptors and D2-dopamine receptors, which are associated with mood improvements. In vitro studies have shown that it does not interact much with benzodiazepine receptors or gamma-aminobutyric acid (GABA) receptors. More research is needed to understand how buspirone helps ease anxiety symptoms.

How Long Does it Take for Buspirone to Work?

Buspirone generally begins to work within 2 weeks after the initial dose. This medication typically does not produce full therapeutic effects until 4 to 6 weeks after the initial dose.

Do Not Use Buspirone If:

There are situations where this medication may not be the right choice for you. According to the FDA, the following should not use buspirone:

  • Individuals with a hypersensitivity to buspirone hydrochloride
  • Use of a monoamine oxidase inhibitors (MAOIs) within 14 days of taking Buspirone

Please note that this list may not be complete, and there may be other situations where use of this drug is not advisable.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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