This study aimed to examine the cognitive benefits of Magtein®PS, a formulation containing magnesium L-threonate (Magtein®) and phosphatidylserine plus vitamins C and D, in healthy Chinese adults.

The second-most abundant intracellular mineral, magnesium (Mg), is a cofactor for more than 300 enzymatic reactions and is, therefore, essential to the functioning of numerous metabolic pathways within the body. Energy is generated by every cell. As a result, proteins are produced, genes are regulated, bones and teeth are maintained, and the brain and nervous system function.

There are abundant sources of magnesium in the food supply, including grains, cereals, and dark leaves, such as spinach and cabbage. However, despite the abundance of magnesium in the Chinese food supply, the consumption of magnesium in the Chinese population is below the recommended amount of 330 mg/day recommended by the China Nutrition Society.

It has been reported that 2373 adults in Guangxi, China, of both sexes, consumed an average amount of 205 mg of magnesium per day, suggesting the need for supplementation.

In subjects prone to mental stress, magnesium supplementation has improved migraine headache symptoms, Alzheimer’s disease symptoms, stroke symptoms, and subjective anxiety. In addition, magnesium intake has been linked to lower depression symptoms.

There is also a relationship between magnesium and anxiety. For example, test anxiety is associated with increased urinary magnesium excretion, which leads to a partial reduction in serum magnesium levels, as indicated by an analysis of data from the National Health and Nutrition Survey (NHANES) between 2011 and 2014.

Methodology & Results

A total of 109 participants (18-65 years old) were enrolled in the study, including 54 experimental and 55 control subjects.

In this study, subjects were given either Magtein®PS or placebo (starch) capsules at a daily dose of 2 g. In addition, a clinical memory test, commonly used in Chinese hospitals and academic institutes to evaluate cognitive function, was administered before and after the supplement.

Even though the researchers only evaluated cognitive function in this study, Magtein® may likely be a useful supplement for many purposes. For instance, magnesium supplementation may benefit those suffering from treatment-resistant depression.

It is thought that increasing magnesium levels in the brain can alleviate migraine headaches, Alzheimer’s disease, stroke, and subjective anxiety in people who are prone to mental stress, which explains why magnesium supplementation is so beneficial for these conditions.

Significant improvement was observed in all five subcategories and overall memory quotient scores for subjects receiving Magtein®PS compared to those in the control group. As a result, older participants showed greater improvement than younger participants, demonstrating that Magtein®PS improved memory and cognition.

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