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It is possible to go through withdrawal when stopping doxepin. For this reason, it is better to gradually reduce the medication before stopping completely; it can help reduce doxepin withdrawal symptoms and discomfort. 

How Long Do Doxepin Withdrawal Symptoms Last?

It can take up to three weeks for the withdrawal symptoms from doxepin to wear off completely. 

Withdrawal Symptoms

The symptoms of withdrawal from doxepin can include headache, nausea, and generally flu-like discomfort. The best way to avoid these symptoms is to gradually stop taking the medication. 


Due to doxepin’s prolonged half-life, withdraw symptoms are typically not observed after suddenly stopping this medication. Though gradually stopping the medication can lessen or even eliminate withdrawal from this drug. 

Treatment Options

Someone experiencing withdrawal from doxepin should treat the symptoms. For example, take over-the-counter (OTC) pain medication for head and body aches. 

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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