OverviewDosageSide EffectsInteractionsHalf-Life

Doxepin topical hydrochloride cream contains approximately 50 mg of doxepin hydrochloride for the short-term treatment of moderate pruritus (itching) in adults. Itching may be due to atopic dermatitis (eczema) or lichen simplex chronicus (LSC).

What is Doxepin Topical Hydrochloride Cream?

Doxepin is a dibenzoazepine tricyclic antidepressant. While experts are not sure how this medication affects itching, it may be due to the fact that doxepin has H1 histamine receptor-blocking activity. Histamines are part of the body’s immune response, and can cause side effects like inflammation and itching. Therefore, blocking the actions of histamine receptors could provide a relief from itching.


Doxepin is for treatment of itching from atopic dermatitis (eczema) or other skin conditions. 


Is doxepin hydrochloride cream used for pain?

Doxepin hydrochloride cream can have an analgesic, or painkilling, effect. So, even though painkilling is not its primary purpose, it might provide relief from pain, including neuropathic pain.  

Can doxepin stop itching?

This drug helps prevent histamine side effects, so it will be useful in treating some kinds of itching, such as those due to eczema

Is doxepin used for allergies?

Doxepin has demonstrated histamine-blocking activity. Specifically, it blocks H1 and H2 receptors, both heavily associated with allergy symptoms. So, this medication may treat some allergy symptoms like hives.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

More about Doxepin


Written by

Fact Checked by