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Xeljanz (tofacitinib) is not addictive; there are typically no withdrawal symptoms associated with this drug. In fact, a small clinical study found that 37% of people achieved remission for over 49 weeks after stopping this medication. However, due to the pain and swelling associated with rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, some people may experience a flare-up of the disease following Xeljanz withdrawal.

How Long Do Xeljanz Withdrawal Symptoms Last?

There are no withdrawal symptoms from the drug. People may experience a return of the disease symptoms, though.

Withdrawal Symptoms

Withdrawal symptoms will be related to the disease a patient has. People may experience joint pain, swelling or inflammation from rheumatoid arthritis and psoriatic arthritis, or inflammation and pain from ulcerative colitis.


People who stop taking Xeljanz under physician orders should not begin this treatment again unless directed by a physician.

Treatment Options

Patients should speak with their doctors regarding treatment options if they experience any disease flare-ups following Xeljanz discontinuation. Physicians will provide the appropriate recommendations based on a patient’s unique medical history.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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