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Hydrochlorothiazide and alcohol interactions can occur. Specifically, consuming alcohol while taking hydrochlorothiazide can cause orthostatic hypotension, a serious condition that causes a person’s blood pressure to drop when they sit up or stand up quickly.

Side Effects

Taking hydrochlorothiazide and alcohol can cause the following side effects:

  • Orthostatic hypotension (postural low blood pressure)


Hydrochlorothiazide and alcohol can interact in ways that enhance the antihypertensive, or blood pressure-lowering, effect of hydrochlorothiazide. Namely, this interaction can cause headache, dizziness, lightheadedness, fainting, and changes in a person’s heart rate and blood pressure.

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