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There are several other drugs and biologics that could work as an alternative to Stelara (ustekinumab).

Stelara Alternatives for Psoriasis

Otezla (Apremilast)

Otezla (apremilast) is an option to treat plaque psoriasis and psoriatic arthritis. Unlike Stelara, which is delivered via injection, Otezla is a once-daily oral tablet. Like Stelara, it is a long-term treatment option. Apremilast can affect mood and even trigger thoughts of suicide. Anyone experiencing these symptoms should contact their doctor right away.

Humira (Adalimumab) and Other Tumor Necrosis Factor-Alpha Inhibitors

Humira (adalimumab) is also a biologic, but it works by blocking TNF-alpha, which can stop the inflammatory cycle. Like Stelara, it can affect the immune system and increase the risk of infection. Humira is delivered in a subcutaneous injection like Stelara, as well. 

Cosentyx (Secukinumab) and Other Interleukin 17 (IL-17) Inhibitors

Cosentyx (secukinumab) is similar to Stelara in many ways. For example, patients receive it via injection and it also increases one’s risk of upper respiratory infection. 

Stelara Alternatives for Crohn’s Disease

Humira (Adalimumab) and Other Tumor Necrosis Factor-Alpha Inhibitors

Like Stelara, Humira (adalimumab) is a biologic available for psoriasis and Crohn’s disease. It is one of a number of TNF-alpha inhibitors that work to control inflammation. 


Prednisone (Rayos, Prednisone Intensol, Deltasone) is a steroid medication that may treat a number of inflammatory diseases, including Crohn’s. It tends to be more of a short-term solution, however, unlike ustekinumab.


Remicade (infliximab) is a chimeric monoclonal antibody available to treat a number of autoimmune diseases, including Crohn’s. It is injected into a vein once every six to eight weeks. 


What is the generic for Stelara?


Is Stelara the same as Humira?

It is a biologic like Humira (adalimumab), although it blocks a different protein. Humira is a TNF-alpha inhibitor while Stalara works by blocking interleukin 12 and interleukin 23.

Is Stelara a Part B drug?

Most likely, Part B will cover the cost of Stelara as it generally pays for biological agents. Someone considering it should check with Medicare to be certain, though.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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