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Humira (adalimumab) and Stelara (ustekinumab) are two extremely similar biologic drugs. 

Stelara

Stelara works as an interleukin 12 and interleukin 23 antagonist. 

Uses

  • Psoriasis
  • Psoriatic arthritis
  • Crohn’s disease
  • Ulcerative colitis

Humira

Humira is a TNF-alpha inhibitor. 

Uses

  • Rheumatoid Arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis (Bechterew’s disease)
  • Crohn’s disease
  • Ulcerative colitis
  • Psoriasis
  • Hidradenitis suppurativa (acne inversa)
  • Uveitis (chorioretinitis)
  • Behcet’s syndrome

Which Is More Effective?

It’s difficult to say one is more effective than the other, as they have similar side effects and risk factors. They also both work by dampening the immune system. It is therefore up to a physician to determine which is the better choice in each situation.

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