Below are the general guidelines for dosing dupixent. Note that these dosages may be adjusted on a case-by-case basis for individual patients by a provider. Always follow your prescribing physician’s instructions for taking dupixent.
The following information comes from DailyMed, the official FDA label information provider for drugs.
What if I miss a dose of Dupixent?
If you miss a dose of this medicine, take it as soon as possible. (within a day of missed dose) Get back onto your regular schedule. Do not double doses.
If you miss a dose and it is within 7 days from the missed dose, use a dose as soon as possible and go back to your regular dosing schedule. If you miss a dose and it is more than 7 days, skip the missed dose and go back to your regular schedule.
What if I overdose on Dupixent?
There is no specific treatment for dupixent overdose. In the event of overdosage, monitor the patient for any signs or symptoms of adverse reactions and institute appropriate symptomatic treatment immediately.
How is Dupixent administered?
DUPIXENT is administered by subcutaneous injection. Patients can administer themselves with proper training or by a caregiver.
Dosing in Adults
The recommended dose of DUPIXENT for adult patients is an initial dose of 600 mg (two 300 mg injections), followed by 300 mg given every other week (Q2W).
Dosing in Pediatric Patients (6 to 17 Years of Age)
The recommended dose of DUPIXENT for patients 6 to 17 years of age is specified in Table 1.
|Body Weight||Initial Dose||Subsequent Doses|
|15 to less than 30 kg||600 mg (two 300 mg injections)||300 mg every 4 weeks (Q4W)|
|30 to less than 60 kg||400 mg (two 200 mg injections)||200 mg every other week (Q2W)|
|60 kg or more||600 mg (two 300 mg injections)||300 mg every other week (Q2W)|
Concomitant Topical Therapies
DUPIXENT can be used with or without topical corticosteroids. Topical calcineurin inhibitors may be used, but should be reserved for problem areas only, such as the face, neck, intertriginous and genital areas.
The recommended dose of DUPIXENT for adults and adolescents (12 years of age and older) is:
- an initial dose of 400 mg (two 200 mg injections) followed by 200 mg given every other week or
- an initial dose of 600 mg (two 300 mg injections) followed by 300 mg given every other week
- for patients with oral corticosteroids-dependent asthma, or with co-morbid moderate-to-severe atopic dermatitis for which DUPIXENT is indicated, start with an initial dose of 600 mg followed by 300 mg given every other week
Chronic Rhinosinusitis with Nasal Polyposis
The recommended dose of DUPIXENT for adult patients is 300 mg given every other week.
Important Administration Instructions
DUPIXENT is intended for use under the guidance of a healthcare provider. A patient may self-inject DUPIXENT after training in subcutaneous injection technique using the pre-filled syringe. In adolescents 12 years of age and older, it is recommended that DUPIXENT be given by or under the supervision of an adult. Dupixent pre-filled syringe should be given by a caregiver in children 6-11 years of age. Provide proper training to patients and/or caregivers on the preparation and administration of DUPIXENT prior to use according to the “Instructions for Use”.
For atopic dermatitis and asthma patients taking an initial 600 mg dose, administer each of the two DUPIXENT 300 mg injections at different injection sites.
For atopic dermatitis and asthma patients taking an initial 400 mg dose, administer each of the two DUPIXENT 200 mg injections at different injection sites.
Administer subcutaneous injection into the thigh or abdomen, except for the 2 inches (5 cm) around the navel. The upper arm can also be used if a caregiver administers the injection.
Rotate the injection site with each injection. DO NOT inject DUPIXENT into skin that is tender, damaged, bruised, or scarred.
If a dose is missed, instruct the patient to administer the injection within 7 days from the missed dose and then resume the patient’s original schedule. If the missed dose is not administered within 7 days, instruct the patient to wait until the next dose on the original schedule.
The DUPIXENT “Instructions for Use” contains more detailed instructions on the preparation and administration of DUPIXENT [see Instructions for Use].
Preparation for Use of DUPIXENT Pre-filled Syringe with Needle Shield
Before injection, remove DUPIXENT pre-filled syringe from the refrigerator and allow DUPIXENT to reach room temperature (45 minutes for the 300 mg/2 mL pre-filled syringe and 30 minutes for the 200 mg/1.14 mL pre-filled syringe) without removing the needle cap.
Inspect DUPIXENT visually for particulate matter and discoloration prior to administration. DUPIXENT is a clear to slightly opalescent, colorless to pale yellow solution. Do not use if the liquid contains visible particulate matter, is discolored or cloudy (other than clear to slightly opalescent, colorless to pale yellow). DUPIXENT does not contain preservatives; therefore, discard any unused product remaining in the pre-filled syringe.
How is Dupixent supplied?
DUPIXENT (dupilumab) Injection is a clear to slightly opalescent, colorless to a pale yellow solution, supplied in single-dose prefilled syringes with needle shield. Each pre-filled syringe with needle shield is designed to deliver either 300 mg of DUPIXENT in 2 mL (NDC 0024-5914-00) or 200 mg of DUPIXENT in 1.14 mL solution (NDC 0024-5918-00).
DUPIXENT is available in cartons containing 2 pre-filled syringes with needle shield.
|Pack Size||300 mg/2 mL Pre-filled Syringe with Needle Shield||200 mg/1.14 mL Pre-filled Syringe with Needle Shield|
|Pack of 2 syringes||NDC 0024-5914-01||NDC 0024-5918-01|
Storage and Handling
DUPIXENT is sterile and preservative-free. Discard any unused portion.
Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light.
If necessary, pre-filled syringes may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, DUPIXENT must be used within 14 days or discarded.
Do not expose the pre-filled syringe to heat or direct sunlight.
Do NOT freeze. Do NOT shake.