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Below are the general guidelines for dosing omeprazole. Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking omeprazole.

The following information comes from DailyMed, an FDA label information provider.

IndicationDosage of OmeprazoleTreatment Duration
Treatment of Active Duodenal Ulcer20 mg once daily4 weeks1
Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer RecurrenceTriple Therapy
Omeprazole 20 mg
Amoxicillin 1000 mg
Clarithromycin 500 mg

Take all three drugs twice daily
10 days
In patients with an ulcer present at the time of initiation of therapy, continue omeprazole 20 mg once daily for an additional 18 days for ulcer healing and symptom relief.
Dual Therapy
Omeprazole 40 mg once daily
Clarithromycin 500 mg three times daily
14 days
In patients with an ulcer present at the time of initiation of therapy, an additional 14 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief.
Active Benign Gastric Ulcer40 mg once daily4 to 8 weeks
Treatment of Symptomatic GERD20 mg once dailyUp to 4 weeks
Treatment of EE due to Acid- Mediated GERD20 mg once daily4 to 8 weeks2
Maintenance of Healing of EE due to Acid-Mediated GERD20 mg once daily3Controlled studies do not extend beyond 12 months.
Pathological Hypersecretory ConditionsStarting dose is 60 mg once daily; adjust to patient needs
Daily dosages of greater than 80 mg should be administered in divided doses.
Dosages up to 120 mg three times daily have been administered.
As long as clinically indicated.
Some patients with Zollinger- Ellison syndrome have been treated continuously for more than 5 years.


Table 2 shows the recommended dosage of omeprazole in pediatric patients by indication.

Table 2: Recommended Dosage Regimen of Omeprazole in Pediatric Patients by Indication

IndicationOmeprazole Dosage Regimen and Duration
Patient AgeWeight-Based Dose (mg)Regimen and Duration
Treatment of Symptomatic GERD1 to 16 years5 to less than 10 kg: 5 mgOnce daily for up to 4 weeks
10 to less than 20 kg: 10 mg
20 kg and greater: 20 mg
Treatment of EE due to Acid-Mediated GERD1 to 16 years5 to less than 10 kg: 5 mgOnce daily for 4 to 8 weeks1
10 to less than 20 kg: 10 mg
20 kg and greater: 20 mg
1 month to less than 1 year3 to less than 5 kg: 2.5 mgOnce daily up to 6 weeks
5 to less than 10 kg: 5 mg
10 kg and greater: 10 mg
Maintenance of Healing of EE due to Acid-Mediated GERD1 to 16 years5 to less than 10 kg: 5 mgOnce daily. Controlled studies do not extend beyond 12 months
10 to less than 20 kg: 10 mg
20 kg and greater: 20 mg

What if I miss a dose of Omeprazole?

According to Mayo Clinic, If you miss a dose of omeprazole, you should take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

What if I overdose on Omeprazole?

Reports have been received of overdosage with omeprazole in humans. Doses ranged up to 2400 mg (120 times the usual recommended clinical dose). Manifestations were variable but included confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, dry mouth, and other adverse reactions similar to those seen in normal clinical experience. Symptoms were transient, and no serious clinical outcome has been reported when omeprazole was taken alone. No specific antidote for omeprazole overdosage is known. Omeprazole is extensively protein bound and is, therefore, not readily dialyzable. In the event of overdosage, treatment should be
symptomatic and supportive.

As with the management of any overdose, the possibility of multiple drug ingestion should be considered. For current information on the treatment of any drug overdose, contact a Poison Control Center at 1­ 800-222-1222.

Single oral doses of omeprazole at 1350, 1339, and 1200 mg/kg were lethal to mice, rats, and dogs, respectively. Animals were given these doses showed sedation, ptosis, tremors, convulsions, and decreased activity, body temperature, and respiratory rate, and increased depth of respiration.

How is Omeprazole administered?

Omeprazole Delayed-Release Capsules should be taken before eating. In the clinical trials, antacids were used concomitantly with omeprazole. Patients should be informed that the omeprazole Delayed-Release Capsule should be swallowed whole. For patients unable to swallow an intact capsule, alternative administration options are available. Omeprazole capsules may be opened and mixed with applesauce or similar food, and swallowed right away. (DO NOT CRUSH OR CHEW THIS MIXTURE)

How is Omeprazole supplied?

Omeprazole Delayed-Release Capsules, 10 mg, are opaque, hard gelatin, apricot, and amethyst colored capsules coded 606 on cap and PRILOSEC 10 on the body.

Omeprazole Delayed-Release Capsules, 20 mg, are opaque, hard gelatin, amethyst colored capsules, coded 742 on cap and PRILOSEC 20 on the body.

Omeprazole Delayed-Release Capsules, 40 mg, are opaque, hard gelatin, apricot, and amethyst colored capsules coded 743 on cap and PRILOSEC 40 on the body.

Omeprazole For Delayed-Release Oral Suspension, 2.5 mg or 10 mg, is supplied as a unit dose packet containing a fine yellow powder, consisting of white to brownish omeprazole granules and pale yellow inactive granules

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