OverviewDosageSide EffectsInteractionsHalf-Life

Omeprazole is currently the 7th most commonly prescribed drug in the United States, with almost 59,000,000 prescriptions in 2017. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long omeprazole stays in your system.

The FDA states the following information regarding omeprazole half-life:

Mean effective half-life: 0.5 to 1 hour

Terminal phase half-life: 40 min

Omeprazole has an oral bioavailability of about 30 to 40% at doses of 20 to 40 mg. Plasma concentration peaks within 0.5 hours, and the drug is rapidly absorbed, generally within 0.5 to 3.5 hours. It clears from the plasma within 4 hours, and it is completely metabolized by the liver. Metabolites are excreted mostly in the urine, and the rest via bile.  Even though the half life is relatively short there is the largest effect at 24 hours, and can assist with reducing stomach acid secretion for up to 72 hours.

What is the half-life of omeprazole?

The half-life omeprazole is less than 1 hour.

How long does omeprazole stay in your system?

  • Urine: Proton pump inhibitors like omeprazole may cause a false-positive result on a THC test, according to some research. While the evidence is scant and not well supported, those who need to take a THC test and take proton pump inhibitors should alert the testing agency of this fact.
  • Serum: Omeprazole reaches peak serum concentration within 0.5 to 3.5 hours, and has a total body clearance of 500-600 mL/min.

Does omeprazole last 24 hours?

After oral administration, the onset of the antisecretory effect of omeprazole occurs within one hour, and the inhibition of stomach acid secretion can last up to 72 hours.

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