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Generally, you can stop omeprazole without reducing the dose first. But if you have used it for a long time, suddenly interrupting may make your stomach produce a lot more acid, and your symptoms may come back. It is, therefore, recommended that you speak to your doctor before you stop.

How Long Do Omeprazole Withdrawal Symptoms Last?

When you stop omeprazole, your stomach may increase the acid secretion significantly. Therefore, it is unsurprising that a common side effect of omeprazole withdrawal is a return of heartburn symptoms. However, acid secretion in your stomach should return to normal within two weeks.

Withdrawal Symptoms

Symptoms of omeprazole withdrawal may vary, but scientific studies indicate that some discontinuation symptoms may include: heartburn, which is the most common, indigestion, and acid regurgitation (reflux). Omeprazole withdrawal symptoms are probably due to an increase in stomach acidity. 


Although most individuals will have no major issues with the discontinuation of omeprazole, others may experience unpleasant withdrawal symptoms. In particular, those who take high-dose omeprazole might be at greater risk of severe withdrawal symptoms.

Treatment Options

Reducing the dose gradually, especially when taking high-dose omeprazole, may help prevent severe withdrawal symptoms.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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