Interactions between omeprazole and alcohol have not been observed. However, drinking alcohol can worsen heartburn, ulcers, and GERD symptoms and it is, therefore, best avoided.
Omeprazole can sometimes make you feel dizzy. Drinking alcohol is likely to make this sensation worse.
Alcohol does not affect how omeprazole works, so it is typically fine to drink alcohol in moderation while taking omeprazole. However, alcohol can worsen your symptoms and it is, therefore, recommended that you avoid it altogether.