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Omeprazole is not the only drug that treats heartburn, ulcers, GERD, and Zollinger-Ellison syndrome.

Potential Alternatives for Omeprazole

Other proton pump inhibitors 

Other proton pump inhibitors include esomeprazole (Nexium), pantoprazole (Protonix), and lansoprazole (Prevacid).

Other antacids and non-proton pump inhibitor medicines

Others antacids and non-proton pump inhibitor drugs are Maalox, Mylanta, and Tums; ranitidine (Zantac), famotidine (Pepcid), and cimetidine (Tagamet) are H2 (histamine) receptor antagonists.

Non-medical alternatives

Non-medical alternatives that you can talk to your doctor about include:

  • Acupuncture
  • Melatonin
  • Hypnotherapy (clinical hypnosis)
  • Herbal remedies, such as chamomile, ginger root, marshmallow root, and slippery elm
  • Baking soda
  • Chewing gum
  • Aloe juice
  • Almonds
  • Avoiding certain foods that you notice may worsen GERD

However, scientific research on how effective these alternatives are is scarce.

Lifestyle changes

Lifestyle changes can help, too. These changes may include:

  • Quitting smoking
  • Exercising regularly
  • Sleeping on the left side
  • Elevating the head and upper body while in bed
  • Wearing loose-fitting clothing
  • Eating smaller meals more often
  • Reducing alcohol intake
  • Avoid eating late at night before bed

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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