OverviewDosageSide EffectsInteractionsHalf-Life

Below are the general guidelines for dosing Trulicity (dulaglutide). Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking Trulicity.

The following information comes from DailyMed, an FDA label information provider.

What if I miss a dose of Trulicity?

According to Mayo Clinic, if you miss a dose of Trulicity, take it as soon as possible within three days of missing it, unless you are closer to the time of your next dose. If the latter is true, skip the missed dose and wait until your next one. Never double dose.

What if I overdose on Trulicity?

Overdoses have been reported in clinical studies. Effects associated with these overdoses were primarily mild or moderate gastrointestinal events (e.g., nausea, vomiting) and non-severe hypoglycemia. In the event of overdose, appropriate supportive care (including frequent plasma glucose monitoring) should be initiated according to the patient’s clinical signs and symptoms.

Dosage and Administration

2.1 Dosage

The recommended initiating dose of TRULICITY is 0.75 mg once weekly. The dose may be increased to 1.5 mg once weekly for additional glycemic control. The maximum recommended dose is 1.5 mg once weekly.

Administer TRULICITY once weekly, any time of day, with or without food. TRULICITY should be injected subcutaneously in the abdomen, thigh, or upper arm.

If a dose is missed, instruct patients to administer as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days remain before the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.

The day of weekly administration can be changed if necessary as long as the last dose was administered 3 or more days before.

2.2 Concomitant Use with an Insulin Secretagogue (e.g., Sulfonylurea) or with Insulin

When initiating TRULICITY, consider reducing the dosage of concomitantly administered insulin secretagogues (e.g., sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings and Precautions (5.3)].

2.3 Important Administration Instructions

Prior to initiation of TRULICITY, patients should be trained by their healthcare professional on proper injection technique. Training reduces the risk of administration errors such as improper injection site, needle sticks, and incomplete dosing. Refer to the accompanying Instructions for Use for complete administration instructions with illustrations. The instructions can also be found at www.trulicity.com.

When using TRULICITY with insulin, instruct patients to administer as separate injections and to never mix the products. It is acceptable to inject TRULICITY and insulin in the same body region but the injections should not be adjacent to each other.

When injecting in the same body region, advise patients to use a different injection site each week. TRULICITY must not be administered intravenously or intramuscularly.

TRULICITY solution should be visually inspected for particulate matter and discoloration prior to administration.

How is Trulicity supplied?

16.1 How Supplied

Each TRULICITY single-dose pen is packaged in a cardboard outer carton.

Carton of 4 Single-Dose Pens

  • 0.75 mg/0.5 mL solution in a single-dose pen (NDC 0002-1433-80)
  • 1.5 mg/0.5 mL solution in a single-dose pen (NDC 0002-1434-80)

16.2 Storage and Handling

  • Store TRULICITY in the refrigerator at 36°F to 46°F (2°C to 8°C). Do not use TRULICITY beyond the expiration date.
  • If needed, each single-dose pen can be kept at room temperature, not to exceed 86°F (30°C) for a total of 14 days.
  • Do not freeze TRULICITY. Do not use TRULICITY if it has been frozen.
  • TRULICITY must be protected from light. Storage of TRULICITY in the original carton is recommended until time of administration.
  • Discard the TRULICITY single-dose pen after use in a puncture-resistant container.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


More About Trulicity

Written by

Medically reviewed by