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Over 160,000 people in the United States are prescribed Cosentyx to help manage their plaque psoriasis, psoriatic arthritis, and, as of June 2020, non-radiographic axial spondyloarthritis. People who take this medication (or are considering taking it) would benefit from knowing a little bit more about this drug, including how long Cosentyx stays in your system.

Experts state the following information regarding secukinumab (Cosentyx) half-life:

Mean elimination half-life: 22 to 31 days following IV and SC doses for plaque psoriasis patients

Terminal half-life: ~25.7 days

Time to steady-state: After 24 weeks following the “every 4 week dosing regimens”

Peak plasma concentrations: about 6 days after a single 150 mg or 300 mg SC dose for plaque psoriasis patients

Accumulation ratio: ~2 (following “a 4‐week dosing interval and a terminal half‐life of approximately 4 weeks”)


What is the half-life of Cosentyx?

The FDA states the mean elimination half-life of Cosentyx (secukinumab) is approximately 22 to 31 days for plaque psoriasis patients.

How long does Cosentyx stay in your system?

Given the half-life of 22 to 31 days, Cosentyx could stay in your system anywhere from 121 to 170.5 days. Of course, half-life could be extended in certain patients, further extending the time secukinumab stays in the body.

How often do you take Cosentyx?

The general dosage of Cosentyx is once per month, after an initial dose once per week for four weeks, although this may vary from one patient to another and for different types of psoriasis. Be sure to speak with your doctor about your individual dose, as well as best practice as to when to take it.

For more in-depth and specific information on Cosentyx dosage, visit our dosage page.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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