OverviewDosageSide EffectsInteractionsHalf-Life

Diclofenac (Flector, Cambia, Zorvolex) was the 94th most commonly prescribed drug in the United States in 2017. In that year alone, there were over 8.5 million prescriptions issued for it. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long diclofenac stays in your system.

Basic Information

Mean effective half-life: 2.3 hours (may be less in different formulation)

Terminal phase half-life: 2.3 hours 

Diclofenac has an oral bioavailability of 50 percent. Diclofenac absorption is through the gastrointestinal tract, and it does not accumulate. 


What is the half-life of diclofenac?

The half-life of diclofenac is about 2.3 hours. 

How long does diclofenac stay in your system?

Diclofenac does not show up in a standard drug screening and should only be in the system for around 15 hours. 

Is diclofenac stronger than tramadol?

Tramadol (ConZip, Ultram), an opioid, and diclofenac, an NSAID, both are effective for pain relief but both work in completely different ways. There is some indication that diclofenac may be the better choice for some kinds of pain, though, such as arthritic or post-surgical pain. 

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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