Slow elimination half-life: 1 to 3 days after acute administration; 4 to 6 days after chronic administration
Mean terminal half-life: 8.6 days after single dose; 9.3 days after multiple doses
- “Steady-state levels” after prolonged administration: 4 to 5 weeks
What is the half-life of fluoxetine?
The average half-life of fluoxetine is about 2 to 4 days. It generally takes around 2 to 4 weeks for fluoxetine to have an antidepressant effect, according to a 2020 study.
How long does fluoxetine stay in your system?
It takes about 25 days for fluoxetine to get out of your body, according to Harvard Health.