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As is the case with any other medication, there may be some instances where baclofen interactions can occur. In such cases, use is not recommended, or use will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with this medication include the following.

  • CNS depressants such as diazepam (Valium) clonazepam (Klonopin) and alprazolam (Xanax)
  • Alcohol
  • Hydroxyzine
  • Dronabinol
  • Any medication that causes CNS depressant effect as exacerbation of this effect may occur

Please note that this list is not complete, and other interactions with drugs not listed here may occur.

Gabapentin (Neuraptine)

Gabapentin is an anticonvulsant medication used to treat partial seizures, hot flashes, restless leg syndrome, and neuropathic pain. It is under multiple brand names, including Neuraptine. One of the most common side effects of this drug is sleepiness and dizziness. 

Taking gabapentin and baclofen together may enhance the side effects of these drugs such as dizziness, drowsiness, and confusion. 

Valium (Diazepam)

Diazepam is a benzodiazepine known for its calming effect. It is sold under the brand name Valium and is prescribed to treat anxiety, seizures, alcohol withdrawal, benzo withdrawal syndrome, insomnia, restless leg syndrome, and muscle spasms. 

Taking diazepam and baclofen together may enhance the side effects of these drugs, such as dizziness, drowsiness, and confusion. 

Tramadol (ConZip)

Tramadol is an opioid pain medication prescribed for moderate to severe pain. It has many of the same side effects as opioids, including drowsiness. It is sold under the brand names Ultram and ConZip, among others. 

Both tramadol and baclofen depress the central nervous system. Taking them together can double the effect, leading to respiratory distress, coma, or death. 

Benadryl (Diphenhydramine)

Diphenhydramine is an over-the-counter antihistamine available under many different brand names, including Benadryl. Diphenhydramine is also often found in nighttime pain relievers such as Tylenol PM or Advil PM. One side effect of this drug is sleepiness. 

Taking diphenhydramine and baclofen together may dangerously enhance the side effects of these drugs, such as dizziness, drowsiness, and confusion. 

Xanax (Alprazolam)

Alprazolam is a short-acting tranquilizer used to treat anxiety disorders, specifically panic disorder and generalized anxiety disorder (GAD). 

Taking alprazolam and baclofen together may enhance the side effects of these drugs, such as dizziness, drowsiness, and confusion, so it is critical to discuss this with your doctor.

Food Interactions

There are no known food interactions with baclofen.

Baclofen and Alcohol

For more information, please visit our page on baclofen and alcohol interactions

Disease & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases, and medical conditions that are known to negatively interact with baclofen include:

  • Epilepsy
  • Ovarian cysts

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Baclofen and Pregnancy

For more information, please visit our page on baclofen and pregnancy risks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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